Journal
MICROCHIMICA ACTA
Volume 189, Issue 5, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-022-05292-8
Keywords
Dopamine; Azo reaction; Ag-Au-MIL-101; SERS
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Funding
- National Natural Science Foundation of China [21475088]
- International Joint Laboratory on Resource Chemistry (IJLRC)
- Shanghai Engineering Research Center of Green Energy Chemical Engineering [18DZ2254200]
- Shanghai Frontiers Science Center of Biomimetic Catalysis
- Shanghai Key Laboratory of Rare Earth Functional Materials
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A novel SERS assay for dopamine detection based on azo derivatization reaction exhibits superior sensitivity, selectivity, and stability, free from interference in complex physiological fluid, with potential application in early disease diagnosis.
A specific surface-enhanced Raman scattering (SERS) assay for dopamine (DA) based on an azo derivatization reaction is proposed for the first time by preparation of p-aminothiophenol (PATP)-modified composite SERS substrate, composed of metal-organic framework (MIL-101) decorated with Au and Ag nanoparticles. As the result, the SERS method for detection of the azo reaction between PATP and DA exhibits superior sensitivity, selectivity, and stability. A reasonable linearity in the range 10(-6) to 10(-10) mol.L-1 is achieved, and the limit of detection is 1.2 x 10(-12) mol.L-1. The reactive SERS assay is free from interference in complex physiological fluid. The feasibility of the proposed SERS method for the detection of DA levels in fetal bovine serum (FBS) samples and human serum samples is validated by HPLC-MS methods, displaying promising application potential in early disease diagnosis.
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