Journal
MICROCHEMICAL JOURNAL
Volume 175, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.microc.2021.107123
Keywords
Mixed-mode chromatography; Click chemistry; Ionic liquids; Chiral separation; Stationary phase
Categories
Funding
- National Natural Science Foundation of China [21804112, 21974015]
- talent introduction program of Southwest Medical University [090300040040]
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A novel multimode stationary phase Sil-VMB-NCAD was successfully synthesized using thiol-ene click chemistry, showing enantiomeric separation ability. Characterization methods included NMR, EA, TGA, and FT-IR. The column exhibited multiple retention mechanisms for various analytes and successful enantioseparation.
A novel multimode stationary phase with enantiomeric separation ability named Sil-VMB-NCAD was successfully synthesized by combining ionic liquid embedded octadecyl chains and cellulose derivatives on silicon sphere through thiol-ene click chemistry reaction. The following methods were used to characterize the synthesized stationary phase and its intermediate products: nuclear magnetic resonance spectroscopy (NMR), elemental analysis (EA), thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). Hydrophobic analytes (alkylbenzenes, polycyclic aromatic hydrocarbons and positional isomers), ionic compounds (phenols) and anilines were used to investigate the chromatographic behaviour of the Sil-VMB-NCAD column. Meanwhile, to further elucidate the multiple retention mechanisms of the prepared column, the correlations between retention time of analyte and the composition and pH values of the mobile phase was studied. In addition, the chiral separation ability of the prepared column was demonstrated by successfully separating warfarin, ketoprofen, 1-phenyl-l-propanol and styrene oxide under a reversed-phase mode. These results indicated that the Sil-VMB-NCAD column can provide multimode retention mechanisms for the separation of various analytes and achieve enantioseparation ability.
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