Journal
MICROBIOLOGY-SGM
Volume 168, Issue 3, Pages -Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.001142
Keywords
horizontal gene transfer; metabolic changes (Warburg effect, sphingosine metabolism); antagonistic effectors (e.g. SidM/SidD); common targets (e.g. Rab1); functional redundancy; metaeffectors; most/all eukaryotic organelles/pathways are subverted
Categories
Funding
- Swiss National Science Foundation [31003A_175557, 310030_200706]
- Institut Pasteur
- Fondation pour la Recherche Medicale (FRM) [EQU201903007847]
- Agence Nationale de la Recherche [ANR-10-LABX-62-IBEID]
- Swiss National Science Foundation (SNF) [31003A_175557, 310030_200706] Funding Source: Swiss National Science Foundation (SNF)
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Legionella pneumophila is a facultative intracellular pathogen that infects humans by parasitizing aquatic protozoa. It possesses a large repertoire of unique bacterial effectors that manipulate host cells, leading to severe diseases such as pneumonia.
Legionella pneumophila is an environmental bacterium that parasitizes aquatic protozoa and uses the same processes to infect humans. The facultative intracellular pathogen causes a life-threatening pneumonia with possible systemic complications. The co-evolution with protozoa is reflected in an armoury of bacterial effectors, and many of these type IV-secreted proteins have likely been acquired by interdomain horizontal gene transfer (HGT) from hosts. The unique features of L. pneumophila are the largest bacterial effector repertoire known to date, subversion of virtually all eukaryotic signalling pathways and acquisition of eukaryotic enzyme activities used to manipulate the host cell to the pathogen's advantage.
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