Journal
MEDICINE
Volume 101, Issue 14, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000029128
Keywords
hospital stay; liver cirrhosis; omega-3 fatty acid; parenteral nutrition; variceal bleeding
Categories
Funding
- Clinical Medicine Research Institute at Chosun University Hospital
Ask authors/readers for more resources
This retrospective study investigated the safety and efficacy of omega-3 fatty acid-enriched parenteral nutrition in patients with acute variceal bleeding. The results showed that this nutritional approach significantly reduced the length of hospital stay.
Acute variceal bleeding, a crucial complication of liver cirrhosis requires high energy expenditures but gastrointestinal bleeding limits enteral feeding in the acute stage. We investigated the safety and efficacy of omega-3 fatty acid-enriched parenteral nutrition in acute variceal bleeding patients. In this retrospective study, a total of 208 cirrhotic patients with acute variceal bleeding who underwent parenteral nutrition in the absence of enteral nutrition were enrolled. Among the patients, 86 patients received omega-3 fatty-acid-enriched parenteral nutrition. The primary endpoint was to evaluate the duration of hospital stay and the presence of clinical complications of liver cirrhosis. The mean age of the patients enrolled was 54.9 years-old and 185 patients (88.9%) were male. The cause of liver cirrhosis, Child-Pugh score and comorbidities were statistically not different. Patients with omega-3 enriched parenteral nutrition had a significantly lower systolic blood pressure and total bilirubin levels. The difference in the in-hospital mortality (P = .813) or rate of complications (P = .880) was not statistically significant. The duration of hospital stay was significantly shorter in the patients who underwent omega-3 fatty acid-enriched parenteral nutrition (10.7 +/- 7.3 vs 7.9 +/- 4.2 days, P = .001). In liver cirrhosis patients with acute variceal bleeding, omega-3 fatty acid-enriched parenteral nutrition significantly decreased the length of hospital stay. Further prospective studies to consolidate these findings are warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available