4.2 Article

Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief

Related references

Note: Only part of the references are listed.
Review Immunology

Angiotensin-(1-7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

Filippo Annoni et al.

Summary: Aneurysmal subarachnoid hemorrhage (SAH) is a significant cause of death and disability worldwide. The renin-angiotensin system (RAS) has been proposed as a potential therapeutic target after brain injury. The upregulation of the Ang-(1-7)/MasR axis in the RAS system may have neuroprotective effects in various pathological conditions, including SAH.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia

Mitchell J. Bartlett et al.

Summary: The study examined a glycopeptide BBI-11008 with selective delta-opioid receptor agonism, showing good central penetration and effects on levodopa-induced dyskinesia in rats. The results suggest a balance of mu- and delta-opioid agonism is required for modulation in this model.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Pharmacology & Pharmacy

Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1-7)

Sana Khajehpour et al.

Summary: This article discusses the importance of the protective arm of the renin-angiotensin system and efforts to improve the stability and efficacy of Ang-(1-7) using novel drug delivery systems. By enhancing the protective arm, it may improve therapeutic outcomes for various diseases.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

Article Pharmacology & Pharmacy

Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers

Wafaa Alabsi et al.

Summary: The peptide hormone Angiotensin (1-7) and its related glycopeptide PNA5 have been synthesized and formulated for targeted respiratory delivery, showing high water solubility and amphipathicity. Advanced organic solution spray drying was used to engineer nanoparticles with low residual water content, achieving excellent aerosol dispersion performance. In vitro human cell viability assays demonstrated the biocompatibility and safety of Ang (1-7) and PNA5 for respiratory and brain cells.

PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Glycopeptide drugs: A pharmacological dimension between Small Molecules and Biologics

Christopher R. Apostol et al.

PEPTIDES (2020)

Article Pharmacology & Pharmacy

A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

Meredith Hay et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Review Medicine, General & Internal

Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System

Johanna Schleifenbaum

FRONTIERS IN MEDICINE (2019)

Article Pharmacology & Pharmacy

Decarboxylation of Ang-(1-7) to Ala1-Ang-(1-7) leads to significant changes in pharmacodynamics

Anja Tetzner et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Review Physiology

THE ACE2/ANGIOTENSIN-(1-7)/MAS AXIS OF THE RENIN-ANGIOTENSIN SYSTEM: FOCUS ON ANGIOTENSIN-(1-7)

Robson Augusto Souza Santos et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Cardiac & Cardiovascular Systems

Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms

Tawar Qaradakhi et al.

CARDIOVASCULAR THERAPEUTICS (2017)

Review Pharmacology & Pharmacy

Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22

Sadashiva S. Karnik et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Behavioral Sciences

Cognitive Impairment in Heart Failure: A Protective Role for Angiotensin-(1-7)

Meredith Hay et al.

BEHAVIORAL NEUROSCIENCE (2017)

Review Pharmacology & Pharmacy

Angiotensin (1-7) and Alamandine: Similarities and differences

Tawar Qaradakhi et al.

PHARMACOLOGICAL RESEARCH (2016)

Article Chemistry, Multidisciplinary

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Shayli Varasteh Moradi et al.

CHEMICAL SCIENCE (2016)

Article Multidisciplinary Sciences

Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney

Oliver Domenig et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

Angiotensin A/Alamandine/MrgD Axis: Another Clue to Understanding Cardiovascular Pathophysiology

Jaroslav Hrenak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Cell Biology

Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak

Peter K. Lauf et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

Article Peripheral Vascular Disease

New Components of the Renin-Angiotensin System: Alamandine and the Mas-Related G Protein-Coupled Receptor D

Gisele Maia Etelvino et al.

CURRENT HYPERTENSION REPORTS (2014)

Article Chemistry, Medicinal

Can Amphipathic Helices Influence the CNS Antinociceptive Activity of Glycopeptides Related to β-Endorphin?

Yingxue Li et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Pharmacology & Pharmacy

Mas and Its Related G Protein-Coupled Receptors, Mrgprs

Michael Bader et al.

PHARMACOLOGICAL REVIEWS (2014)

Article Cardiac & Cardiovascular Systems

Discovery and Characterization of Alamandine A Novel Component of the Renin-Angiotensin System

Roberto Queiroga Lautner et al.

CIRCULATION RESEARCH (2013)

Article Pharmacology & Pharmacy

In Vivo Characterization of MMP-2200, a Mixed δ/μ Opioid Agonist, in Mice

John J. Lowery et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Neurosciences

MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability

Robert A. Crozier et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Glycosylation improves the central effects of DAMGO

John J. Lowery et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2007)

Review Chemistry, Multidisciplinary

Glycopeptides related to β-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers

M Dhanasekaran et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Chemistry, Inorganic & Nuclear

Biousian glycopeptides penetrate the blood-brain barrier

RD Egleton et al.

TETRAHEDRON-ASYMMETRY (2005)

Article Biochemistry & Molecular Biology

Identification of a G protein-coupled receptor specifically responsive to β-alanine

T Shinohara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Cardiac & Cardiovascular Systems

Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide

C Berry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Review Chemistry, Organic

Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin

SA Mitchell et al.

JOURNAL OF ORGANIC CHEMISTRY (2001)