Journal
MEDICAL PHYSICS
Volume 49, Issue 7, Pages 4837-4844Publisher
WILEY
DOI: 10.1002/mp.15773
Keywords
current density; edge current; electrode arrays; tumor-treating fields
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2021R1A2C2008695]
- National Research Foundation of Korea [2021R1A2C2008695] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study evaluated methods of constructing electrode arrays to reduce the risk of skin burns during TTFields therapy, and found that inserting an insulator at the edge of each electrode was the most effective method.
Background Tumor-treating fields (TTFields) therapy is increasingly utilized clinically because of its demonstrated efficacy in cancer treatment. However, the risk of skin burns must still be reduced to improve patient safety and posttreatment quality of life. Purpose The purpose of this study was to evaluate the methods of constructing electrode arrays that reduce current density exceeding threshold values, which can cause skin burns during TTFields therapy. Methods Electrode and body models were generated using COMSOL software. The body model had the dielectric properties of the scalp. The average current density beneath the central region of the electrode was maintained at similar to 31 mA/cm(2) RMS. The deviations in current density at the edges of the electrode were reduced by three methods: adjustment of the ceramic thickness ratio of the center to the edge from 1/5 to 4/5, adjustment of the radius of the metal plate from 5.0 to 8.0 mm, and insertion of an insulator of width 0.5 to 2 mm at the edge. Results While using a single circular electrode, adjustment of the ceramic thickness ratio, adjustment of the metal plate radius, and insertion of an insulator near the edge reduced the deviations of current density by 14.6%, 67.7%, and 75.3%, respectively. Similarly, while using circular electrode arrays, inserting an insulator at the edge of each electrode reduced the deviations of current density significantly, from 8.62 to 2.40 mA/cm(2). Conclusions Insertion of an insulator at the edge of each electrode was found to be the most effective method of attaining uniform current density distribution beneath the electrode, thereby lowering the risk of adverse effects of TTFields therapy.
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