Journal
MEDICAL MYCOLOGY
Volume 60, Issue 6, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myac040
Keywords
Candida; gastrointestinal tract; genotyping; colonization
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Funding
- Fondo de Investigacion Sanitaria (FIS. Instituto de Salud Carlos III. Plan Nacional de I + D + I 2017-2020) [PI18/01155, PI19/00074]
- European Regional Development Fund (FEDER) 'A way of making Europe'
- FIS [CPII20/00015]
- Fundacion para Investigacion Sanitaria del Hospital Gregorio Maranon
- Fondo de Investigacion Sanitaria [FI20/00089]
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Gastrointestinal colonization of Candida species is mainly monoclonal and dominated by one genotype.
Gastrointestinal tract Candida genotypes may associate with isolates later causing infections. We genotyped Candida spp isolates (n = 200 individual colonies) from rectal swabs to assess whether gastrointestinal gut colonization is caused by a single genotype (monoclonal pattern) or a combination of them (polyclonal pattern). C. glabrata showed a sheer monoclonal pattern. C. parapsilosis and C. tropicalis showed a monoclonal pattern involving the presence of either exclusively identical genotypes or a combination of clonally-related genotypes; in the latter case, a dominant genotype was always found. C. albicans showed mostly a polyclonal pattern involving a combination of dominant clonally-related genotypes and unrelated genotypes. Lay Summary We genotyped C. albicans, C. parapsilosis, C. tropicalis, and C. glabrata isolates prospectively from rectal swabs to study the gastrointestinal colonization pattern in the patients. Gastrointestinal tract colonization is mostly monoclonal and commonly dominated by one genotype.
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