4.4 Article

Numerical simulation of the vascular structure dependence of blood flow in the kidney

Journal

MEDICAL ENGINEERING & PHYSICS
Volume 104, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2022.103809

Keywords

Biomechanics; Blood flow; Kidney; Vascular structure; Numerical modeling; Computer simulation

Funding

  1. JSPS [20K04281]
  2. Grants-in-Aid for Scientific Research [20K04281] Funding Source: KAKEN

Ask authors/readers for more resources

This study conducted a numerical simulation to investigate the factors influencing renal blood flow. The results showed that blood flow rate and pressure varied among different vessel branches and decreased with vessel diameter. The number and branching style of vessels were found to be important parameters in reproducing renal blood flow. The entire vascular network could generate small variations in physiological flow rate.
A numerical simulation was performed to clarify renal blood flow determination by the vascular structures. Large and small vessels were modeled as symmetric and asymmetric branching vessels, respectively, with simple geometries to parameterize the vascular structures. Modeling individual vessels as straight pipes, Murray's law was used to determine the vessel diameters. Blood flow in the vascular structure was calculated by network analysis based on Hagen-Poiseuille's law. Blood flow simulations for a vascular network segment demonstrated that blood flow rate and pressure vary within the same-generation vessels because of an asymmetric vessel branch while they generally tend to decrease with vessel diameter; thus, the standard deviation of flow rate relative to the mean (relative standard deviation [RSD]) increased from 0.4 to 1.0 when the number of the daughter vessels increased from 3 to 10. Blood flow simulations for an entire vascular network of a kidney showed that the vessel number and branching style, rather than Strahler order, are major parameters in successfully reproducing renal blood flow measured in published experiments. The entire vascular network could generate variation in the physiological flow rate in afferent arterioles at 0.2-0.38 in RSD, which is at least compatible with 0.16 by diameter variation within the same-generation vessels.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available