Journal
MEDICAL DECISION MAKING
Volume 42, Issue 7, Pages 923-936Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0272989X221100717
Keywords
causal forests; heterogeneous treatment effects; machine learning; personalized medicine
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Personalizing treatment recommendations requires understanding the heterogeneity of treatment effects. Machine-learning approaches, such as causal forests, can explore this heterogeneity by considering multiple covariates. This study compares the causal forest method with parametric approaches and finds similar estimates of treatment effectiveness. The results suggest that the permissive hypotension strategy is expected to reduce mortality for most patients, but there is variability in the estimated effects.
Personalizing treatment recommendations or guidelines requires evidence about the heterogeneity of treatment effects (HTE). Machine-learning (ML) approaches can explore HTE by considering many covariates, including complex interactions between them. Causal ML approaches can avoid overfitting, which arises when the same dataset is used to select covariate by treatment interaction terms as to make inferences and reduce reliance on the correct specification of fixed parametric models. We investigate causal forests (CF), a ML method based on modified decision trees that can estimate subgroup- and individual-level treatment effects, without requiring correct prespecification of the effect model. We consider CF alongside parametric approaches for estimating HTE, within the 65 Trial, which evaluates the effect of a permissive hypotension strategy versus usual care on 90-d mortality for critically ill patients aged 65 y or older with vasodilatory hypotension. Here, the CF approach provides similar estimates of treatment effectiveness for prespecified and post hoc subgroups to the parametric approach, and the results of a test for overall HTE show weak evidence of heterogeneity. The CF estimates of individual-level treatment effects, the expected effects of treatment for individuals in subpopulations defined by their covariates, suggest that the permissive hypotension strategy is expected to reduce 90-d mortality for 98.7% of patients but with 95% confidence intervals that include zero for 71.6% of patients. A ML approach is then used to assess the patient characteristics associated with these individual-level effects, and to help target future research that can identify those patient subgroups for whom the intervention is most effective.
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