Bioflavonoid mediated synthesis of TiO2 nanoparticles: Characterization and their biomedical applications

The present study dealt with the rutin mediated synthesis of titanium dioxide nanoparticles (TiO2NPs), their characterization, and evaluation of antibacterial, antidiabetic, and antioxidant properties. XRD spectrum of uncalcined TiO2NPs did not show any distinct diffraction peaks revealing its amorphous nature, while calcinated TiO2NPs showed prominent diffraction peaks indicating its crystalline anatase form. SEM and TEM images helped to understand uniform spherical structure of synthesized uncalcined TiO2NPs, whereas EDX analysis exhibited unique mineral content. Rutin, uncalcined, and calcinated TiO2NPs showed good free radical scavenging, moderate alpha-amylase, and alpha-glucosidase inhibitory activities. Overall, biosynthesized TiO2NPs showed promising antibacterial, antidiabetic, and antioxidant properties with no observed toxicity. Furthermore, these biosynthesized nanoparticles are equally compatible with nanoparticles prepared via chemical methods.

Automated summary

This study successfully synthesized titanium dioxide nanoparticles using rutin as a mediator and evaluated their antibacterial, antidiabetic, and antioxidant properties. The results showed that the biosynthesized nanoparticles exhibited good antioxidant activity and moderate inhibition of alpha-amylase and alpha-glucosidase. Furthermore, these nanoparticles showed no toxicity and had comparable properties to chemically prepared nanoparticles.