Journal
MATERIALS LETTERS
Volume 315, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2022.131973
Keywords
SARS-CoV-2; COVID-19; Molecularly imprinted polymers; Electrochemical sensor; Cyclic voltammetry
Funding
- Center of Excellence on Petro-chemical and Materials Technology (PETROMAT) , Chulalongkorn University
- Postdoctoral Fellowship from Kasetsart University Research and Development Institute (KURDI)
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This study presents an electrochemical polymer composites biosensor for measuring the presence of SARS-CoV-2 whole-virus particles in the environment. Testing showed that the sensor is highly sensitive to SARS-CoV-2 and can differentiate from negative controls.
SARS-CoV-2 is the virus responsible for causing the global COVID-19 pandemic. Identifying the presence of this virus in the environment could potentially improve the effectiveness of disease control measures. Environmental SARS-CoV-2 monitoring may become increasingly demanded in areas where the available testing methods are ineffective. In this study, we present an electrochemical polymer composites biosensor for measuring SARS-CoV2 whole-virus particles in the environment. The sensitized layer was prepared from molecularly imprinted polymer (MIP) composites of inactivated SARS-CoV-2. Testing demonstrated increased sensor signaling with SARS-CoV-2 specifically, while lower responses were observed to the negative controls, H5N1 influenza A virus and non-imprinted polymers (NIPs). This sensor detected SARS-CoV-2 at concentrations as low as 0.1 fM in buffer and samples prepared from reservoir water with a 3 log-scale linearity.
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