Journal
MATERIALS LETTERS
Volume 310, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2021.131510
Keywords
Magnesium alloys; Micro-alloyed; Degradability; Osteogenesis performance
Funding
- National Key R&D Program of China [2018YFC1106600]
- National Natural Science Foundation of China [52071008, 11827803, 31771019, 11421202, 81871788]
- Beijing Natural Science Foundation [2192027]
- Project for Science and Tech-nology leader of Anhui Province [2018H177]
- Fundamental Research Funds for the Central Universities [WK9110000173]
- Anhui Province Science Fund for Distinguished Young Scholars [2108085J40]
- Key Research and Development Plan [912278014064]
Ask authors/readers for more resources
The study demonstrates that Mg-Ca-La alloys with trace La addition exhibit good biocompatibility and stable degradation rate for orthopedic applications. Animal experiments show that implantation of this alloy near bones can promote bone growth without significant adverse effects.
This study describes the development of Mg-Ca-La alloys with trace La addition for orthopedic application, which aims to control the biosafety and degradation simultaneously. The Mg-0.2Ca-0.2La alloy exhibited slow and uniform degradation with only 5.9% reduction in implant volume 12 weeks post-implantation. Cytocompatibility study, using MC3T3-E1, showed significantly higher cell proliferation and osteogenic differentiation on Mg0.2Ca-0.2La alloy surface. When implanted in rat femur, significant bone growth with increased trabecular thickness and number was found around Mg-0.2Ca-0.2La rod. Moreover, no local or systematic adverse effect was observed during the implantation period.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
