Development of an electrochemical nanoplatform for non-enzymatic glucose sensing based on Cu/ZnO nanocomposite

A non-enzymatic amperometric glucose sensor was designed based on Zinc Oxide (ZnO) and copper (Cu) composite membrane. The Copper/Zinc Oxide nanocomposite (Cu/ZnO NC) was elaborated by sol-gel technique, which was then characterized for physico-chemical properties using characterization techniques such as UV-Visible, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and energydispersive X-ray spectroscopy analysis (EDXS). For the sensing electrode fabrication, the synthesized NC was deposited on Glassy Carbon Electrode (GCE) by drop-coating method. The electrochemical behavior of the elaborated sensor was studied through cyclic voltammetry (CV) and chronoamperometry (CA). The Cu/ZnO modified GCE possesses favorable electrocatalytic (EC) properties for the oxidation of glucose in alkaline solution. Furthermore, the suggested sensing nanoplatform for glucose determination had 2 linear ranges: 0.01 mM-1 mM and 1 mM-7 mM, good sensitivity (36.641 mu A mM- 1cm- 2), a limit of detection (LOD) of about 57 mu M, good selectivity as well as a response time of about 8 s. The findings of this study contribute to the applicability of a high-performance non-enzymatic glucose sensor and may potentially act as a significant alternative method for glucose analysis.

Automated summary

A non-enzymatic amperometric glucose sensor based on Zinc Oxide (ZnO) and copper (Cu) composite membrane was designed. The Cu/ZnO nanocomposite was prepared using sol-gel technique and deposited on Glassy Carbon Electrode (GCE) for sensing electrode fabrication. The sensor exhibited favorable electrocatalytic properties for glucose oxidation in alkaline solution, with wide linear ranges, good sensitivity and selectivity, and fast response time.