Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities

Six new aromatic acids (1-6) and three new leucine derivatives containing an unusual oxime moiety (7-9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10-11). The structures of 1-9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1-9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 mu M, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.

Automated summary

Six new aromatic acids and three new leucine derivatives containing an unusual oxime moiety were isolated from a deep-sea-derived actinomycetes strain. These compounds showed potential antimicrobial, cytotoxicity, and antihyperlipidemic effects, with compounds 3 and 4 being the most potent in inhibiting intracellular lipid accumulation.