Journal
MARINE DRUGS
Volume 20, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/md20040259
Keywords
deep-sea actinomycetes; aromatic acids; oximes; antihyperlipidemic
Categories
Funding
- Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDOE [2019] A28, GDNRC2021052]
- Natural Science Foundation of Guangdong Province [2021A1515011711]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- National Natural Science Foundation of China [U20A20101, 31900286, 81973235]
- Administration of Traditional Chinese Medicine of Guangdong Province [20212143]
- Guangdong Local Innovation Team Program [2019BT02Y262]
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Six new aromatic acids and three new leucine derivatives containing an unusual oxime moiety were isolated from a deep-sea-derived actinomycetes strain. These compounds showed potential antimicrobial, cytotoxicity, and antihyperlipidemic effects, with compounds 3 and 4 being the most potent in inhibiting intracellular lipid accumulation.
Six new aromatic acids (1-6) and three new leucine derivatives containing an unusual oxime moiety (7-9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10-11). The structures of 1-9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1-9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 mu M, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.
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