Journal
MARINE DRUGS
Volume 20, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/md20060361
Keywords
Talaromyces flavus; isocoumarins; antioxidant; antibacterial; alpha-glucosidase inhibitory activity; anti-phytopathogenic
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Funding
- Key Science and Technology Program of Hainan Province [ZDKJ202008]
- National Natural Science Foundation of China [32160108, 41866005, 82160675, 81973229]
- Key Research and Development Program of Hainan Province [ZDYF2021SHFZ270, ZDYF2021SHFZ108]
- Hainan Provincial Natural Science Foundation of China [220RC593]
- Innovation Platform for Academicians of Hainan Province Specific Research Fund of The Innovation Platform for Academicians of Hainan Province [YSPTZX202030]
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Six new isocoumarin derivative compounds along with 17 known analogues were isolated from a mangrove-derived fungus. Their structures were identified and their biological activities, including antioxidant and alpha-glucosidase inhibitory activities, were tested. Some compounds showed promising antioxidant and alpha-glucosidase inhibitory activities, highlighting their potential as antioxidants and diabetes control agents.
Six new isocoumarin derivative talaromarins A-F (1-6), along with 17 known analogues (7-23), were isolated from the mangrove-derived fungus Talaromyces flavus (Eurotiales: Trichocomaceae) TGGP35. Their structures were identified by detailed IR, UV, 1D/2D NMR and HR-ESI-MS spectra. The absolute configurations of new compounds were determined by the modified Mosher's method and a comparison of their CD spectra with dihydroisocoumarins described in the literature. The antioxidant, antibacterial, anti-phytopathogenic and inhibitory activity against alpha-glucosidase of all the isolated compounds were tested. Compounds 6-11, 17-19 and 21-22 showed similar or better antioxidant activity than the IC50 values ranging from 0.009 to 0.27 mM, compared with the positive control trolox (IC50 = 0.29 mM). Compounds 10, 18, 21 and 23 exhibited strong inhibitory activities against alpha-glucosidase with IC50 values ranging from 0.10 to 0.62 mM, while the positive control acarbose had an IC50 value of 0.5 mM. All compounds showed no antibacterial or anti-phytopathogenic activity at the concentrations of 50 mu g/mL and 1 mg/mL, respectively. These results indicated that isocoumarins will be useful to developing antioxidants and as diabetes control agents.
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