Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

Automated summary

Transdermal drug delivery using microneedles (MNs) has gained attention in recent years as a safer and painless alternative to hypodermic needle injections. Polymer MNs, among the various materials used, have shown promise in drug delivery and have attracted interest from pharmaceutical and cosmetic companies. This paper reviews the current state of polymer MNs in drug transdermal delivery, discussing their fabrication methods and applications in various fields. It also highlights the challenges and future development trends of MNs.