Journal
MACROMOLECULAR MATERIALS AND ENGINEERING
Volume 307, Issue 8, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.202200009
Keywords
biopolymers; impregnation; processing; supercritical carbon dioxide; thymol
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2022-14/200287, 451-03-68/2022-14/200135, CA18224]
- European Commission
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Chitosan/gelatin and chitosan/gelatin/zeolite films were impregnated with thymol and carvacrol using supercritical carbon dioxide. The resulting films exhibit gradual release of bioactive compounds and are suitable for wound dressing application.
Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method are impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon dioxide at 35 degrees C and 30 MPa, during 18 h. Proposed method enables preparation of biocompatible and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of loaded thymol/carvacrol (TC) mixture are in the range from 3.3% to 6%. After initial burst release, both types of films exhibit gradual release of bioactive compounds, with around 72% and 96% of impregnated TC mixture released in water and phosphate buffered saline solution (pH 7.4) during tested period of 10 days, respectively. Results of water vapor transmission rate (>76 g m(-2) day(-1)) confirm that prepared composites are suitable for wound dressing application. Thermal analysis shows superior properties of prepared TC loaded films compared to control samples. In addition, mechanical and structural properties, as well as solubility and swelling behavior of the obtained films are investigated in detail.
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