Journal
MACROMOLECULAR BIOSCIENCE
Volume 22, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202200015
Keywords
anticancer; antimicrobial; beeswax; core-sheath; electrospinning
Funding
- Bulgarian National Science Fund [Grant.P06-N39/13/2019]
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In this study, composite fibrous materials were successfully prepared by electrospinning poly(ethylene oxide) (PEO) and beeswax (BW). The embedded drug, 5-Nitro-8-hydroxyquinoline (NQ), exhibited antibacterial, antifungal, and anticancer properties. The PEO/BW/NQ fibrous materials showed selective bioactivity against bacteria, fungi, and cancer cells.
Composite fibrous materials are prepared from poly(ethylene oxide) (PEO) and beeswax (BW) by single-spinneret electrospinning using chloroform as a common solvent. The obtained fibers have core-sheath-like structure, as evidenced by the water contact angle values and corroborated by the results on the elemental composition of the fiber's surface determined by X-ray photoelectron spectroscopy (XPS) and by analyses with scanning electron microscopy of fibers before and after selective extraction of PEO or BW. Furthermore, the core-sheath-like structure is proven by transmission electron microscopy. This is attributed to self-assembly of BW molecules on the surface of the formed fibers driven by the incompatibility between PEO and BW. 5-Nitro-8-hydroxyquinoline (NQ) is embedded as a model drug with antibacterial, antifungal, and anticancer properties in the PEO/BW fibrous materials. XPS analyses reveal that NQ is present on the surface of the PEO/BW/NQ materials. Using a purposely designed cell for fixation of the fibrous materials the NQ release in phosphate buffer solution with pH 7.4 is followed. The new PEO/BW/NQ fibrous materials exhibit antibacterial activity against S. aureus and E. coli, antifungal effect against C. albicans, and selective anticancer activity against HeLa (human cervical adenocarcinoma cells) and SH-4 (human melanoma cells) cell lines.
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