Journal
LIFE SCIENCES
Volume 303, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2022.120601
Keywords
Microbiome; Circadian; Metabolism; Systems biology; Gut-Brain Axis; Neurometabolism
Funding
- NIH-NIDDK [F32DK121425]
- NIH [R21DK114652, R21AG053592]
- Novo Nordisk Foundation [NNF-202585]
- NIH
- Novo Nordisk Foundation
- Zymo-CEM Postdoctoral Fellowship (Zymo Research)
- Japan Society for the Promotion of Science (JSPS)
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The gut microbiome has a significant impact on brain metabolism, particularly in regulating circadian rhythms, learning, and behavior.
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
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