Journal
LANGMUIR
Volume 38, Issue 22, Pages 6771-6779Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.2c00812
Keywords
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Funding
- Defense Threat Reduction Agency [HDTRA1-19-1-0007, HDTRA1-18-10003]
- Northwestern University
- Postdoctoral Research Abroad Program - Ministry of Science and Technology (Taiwan) [110-2917-I-564-006]
- Department of Defense through the National Defense Science& Engineering Graduate (NDSEG) Fellowship Program
- Ryan Fellowship
- International Institute for Nanotechnology at Northwestern University
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Isothermal titration calorimetry (ITC) is a technique for measuring the thermodynamic parameters of binding events, which has applications not only in biological macromolecules but also in synthetic systems like metal-organic frameworks (MOFs). Utilizing ITC in MOFs can provide insights into small molecule adsorption mechanisms and the formation of MOF-based composite materials through non-covalent interactions, with specific experimental considerations discussed. Furthermore, underexplored research directions related to MOFs that could benefit from ITC are highlighted.
Isothermal titration calorimetry (ITC) is a techniquewhich directly measures the thermodynamic parameters of binding events.Although historically it has been used to investigate interactions inbiological macromolecules and the kinetics of enzyme-catalyzed reactions,ITC has also been demonstrated to provide relevant thermodynamicinformation about interactions in synthetic systems, such as those inmetal-organic frameworks (MOFs). MOFs are a family of crystallineporous materials that have been widely studied as supports for moleculesranging from gases to biomolecules through physisorption andchemisorption. Herein, we offer a perspective on the current applicationsof ITC in MOFs, including the mechanism of small molecule adsorptionand the formation of MOF-based composite materials through non-covalent interactions. Experimental considerations specific to running ITCexperiments in MOF systems are reviewed on the basis of existing reports. We conclude by discussing underexplored, but promising,MOF-related research directions which could be elucidated by ITC.
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