Efficacy of anti-SARS-CoV-2 monoclonal antibody prophylaxis and vaccination on the Omicron variant of COVID-19 in kidney transplant recipients

Article Biochemistry & Molecular Biology

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Timothee Bruel et al.

Summary: There are differences in neutralizing activity of therapeutic antibodies against the SARS-CoV-2 Omicron BA.1 and BA.2 sublineages, and immunocompromised individuals treated with antibodies show elevated antibody levels but reduced neutralization against Omicron. Breakthrough infections with the Omicron variant are observed in some immunocompromised individuals despite antibody treatment.

NATURE MEDICINE (2022)

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Article Medicine, General & Internal

Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19

Myron J. Levin et al.

Summary: A single dose of AZD7442 showed efficacy in preventing Covid-19 without evident safety concerns. The study suggests that AZD7442 may provide potential protection for individuals who have an inadequate response to vaccination or an increased risk of exposure.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Shuo Feng et al.

Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.

NATURE MEDICINE (2021)

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Letter Urology & Nephrology

Occurrence of severe COVID-19 in vaccinated transplant patients

Sophie Caillard et al.

KIDNEY INTERNATIONAL (2021)

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Letter Medicine, General & Internal

Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

Nassim Kamar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

M. P. O'Brien et al.

Summary: The study indicates that subcutaneous REGEN-COV can effectively prevent severe Covid-19 and reduce the duration of symptoms in individuals at high risk for infection due to household exposure to confirmed SARS-CoV-2 cases.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Urology & Nephrology

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants

Sophie Caillard et al.

KIDNEY INTERNATIONAL (2020)

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Efficacy of anti-SARS-CoV-2 monoclonal antibody prophylaxis and vaccination on the Omicron variant of COVID-19 in kidney transplant recipients

Related references

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Occurrence of severe COVID-19 in vaccinated transplant patients

Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants

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