Journal
KIDNEY INTERNATIONAL
Volume 101, Issue 6, Pages 1110-1112Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2022.04.008
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This study reveals the important role of actin cytoskeleton and cell adhesion in maintaining the stability of CaSR in podocytes, and suggests the potential benefits of calcimimetics in improving podocyte function.
Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Muhlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation of albuminuria and proteinuria was observed in 4 children treated with cinacalcet. Here we discuss the potential mechanisms whereby CaSR displays a favorable effect in podocytes and the context in which calcimimetics may alleviate nephrotic syndrome. Copyright (C) 2022, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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