Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 77, Issue 7, Pages 1335-1343Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glac074
Keywords
Aging; Biochemical parameters; Biomechanic; Brain
Categories
Funding
- Clinical Research Hospital Program from the French Ministry of Health [PHRC 2011-A01091-40]
- Occitania Region research funding (RPBIO 2015) [14054344]
- European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013)
Ask authors/readers for more resources
Frailty is a geriatric syndrome associated with alterations in the central nervous system's biomechanical response. This study found that homocysteine level is independently and positively associated with both the frailty index and the CNS elastance coefficient. Creatinine clearance and folate level were also independently associated with homocysteine level.
Frailty is a geriatric syndrome that combines physiological decline, disruptions of homeostatic mechanisms across multiple physiologic systems and thus, strong vulnerability to further pathological stress. Previously, we provided the first evidence that increased risk of poor health outcomes, as quantified by a frailty index (FI), is associated with an alteration of the central nervous system (CNS) biomechanical response to blood pulsatility. In this study, we explored correlation between 14 biological parameters, the CNS elastance coefficient and FI. We included 60 adults (52-92 years) suspected of normal pressure hydrocephalus and presenting with markers of multiple coexisting brain pathologies, including Parkinson disease, Alzheimer disease, and vascular dementia. We showed that the homocysteine (Hcy) level was independently and positively associated with both the FI and the CNS elastance coefficient (adjusted R-2 of 10% and 6%). We also demonstrated that creatinine clearance and folate level were independently associated with Hcy level. Based on previous literature results describing the involvement of Hcy in endothelial dysfunction, glial activation, and neurodegeneration, we discuss how Hcy could contribute to the altered biomechanical response of the CNS and frailty.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available