4.6 Article

Intravascular hemolysis and multitreatment predict thrombosis in patients with autoimmune hemolytic anemia

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Extensive porto-splenic venous thrombosis postsplenectomy in a sickle cell disease: a rare complication

Tamadher Al Barhi et al.

Summary: Sickle cell disease is a common haematological disorder in Oman, and splenectomy can improve the quality of life for patients. However, a rare complication of this procedure is porto-splenic vein thrombosis. We report a successful case of treating extensive porto-splenic vein thrombosis with early initiation of anticoagulation.

BMJ CASE REPORTS (2022)

Article Hematology

Thromboembolic complications in autoimmune hemolytic anemia: Retrospective study

Deborah Tabita Schaer et al.

Summary: This retrospective study investigated the incidence of thromboembolic events and the relation to complement activation in a cohort of 77 AIHA patients. The results showed that AIHA is associated with an increased risk of thromboembolic events, but there was no correlation with complement activation.

EUROPEAN JOURNAL OF HAEMATOLOGY (2022)

Letter Hematology

Circulating extracellular vesicles and cytokines in congenital and acquired hemolytic anemias

Wilma Barcellini et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Review Hematology

How I treat paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky

Summary: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare complement-mediated hemolytic anemia with diverse manifestations, requiring differentiated treatment approaches; terminal complement inhibition is effective for intravascular hemolysis treatment but not bone marrow failure; novel complement inhibitors under clinical development show promising prospects for future applications.

BLOOD (2021)

Review Medicine, General & Internal

Autoimmune Hemolytic Anemias

Sigbjorn Berentsen et al.

Summary: AIHA is a group of diseases characterized by increased destruction of red cells through autoimmune mechanisms, and recent advancements in diagnosis and treatment have been made. Challenges include wider application of current knowledge, improved understanding of pathogenesis, development of new therapies, and management of refractory cases. Each individual disorder within the AIHA group should be addressed according to their unique differences in cause, pathogenesis, and clinical presentation.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Hematology

It takes two to thrombosis: Hemolysis and complement

Laura Delvasto-Nunez et al.

Summary: Thromboembolic events are the most common complication of hemolytic anemias, involving complement system and hemolysis-induced procoagulant responses, as well as neutrophil activation, inflammation, and vascular damage.

BLOOD REVIEWS (2021)

Article Hematology

Evans syndrome in adults: an observational multicenter study

Bruno Fattizzo et al.

Summary: Evans syndrome is a rare condition characterized by the presence of two autoimmune cytopenias, with treatment involving steroids, intravenous immunoglobulin, and sometimes additional therapies like rituximab. Complications such as bleeding, infections, and thrombosis are common, highlighting the need for prompt therapy and prophylaxis.

BLOOD ADVANCES (2021)

Review Medicine, General & Internal

Thrombotic Complications in Patients with Immune-Mediated Hemolysis

Marco Capecchi et al.

Summary: Autoimmune hemolytic anemias, including autoimmune hemolytic anemia and other immune-mediated anemias, are often associated with a high rate of thrombosis, but lack evidence-based guidance on prevention and management of thrombotic events. Pathophysiological mechanisms for thrombosis in these conditions may involve hemolysis itself and other effects of the immune system. Specific situations, like splenectomy and pregnancy, require particular attention for treatment and prevention of thrombotic complications.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Hematology

Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease-specific treatments: a French nationwide cohort study

Margaux Lafaurie et al.

Summary: For adults with primary immune thrombocytopenia (ITP), older age, history of thrombosis, exposure to corticosteroids, thrombopoietin-receptor agonists (TPO-RAs), and intravenous immunoglobulin (IVIg) were associated with an increased risk of hospitalization for venous thrombosis (VT) and arterial thrombosis (AT). Additionally, a history of cardiovascular diseases and splenectomy also posed a higher risk. Rituximab was not significantly associated with an increased risk of thrombosis in these patients. These findings help to assess thrombotic risk in adult ITP patients and guide treatment selection.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Hematology

COVID-19 and its implications for thrombosis and anticoagulation

Jean M. Connors et al.

BLOOD (2020)

Review Biochemistry & Molecular Biology

Sickle Cell Disease: A Paradigm for Venous Thrombosis Pathophysiology

Maria A. Lizarralde-Iragorri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

New Insights in Autoimmune Hemolytic Anemia: From Pathogenesis to Therapy

Wilma Barcellini et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Hematology

Increased risk of thrombotic events in cold agglutinin disease: A 10-year retrospective analysis

Catherine M. Broome et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

Article Multidisciplinary Sciences

Venous thromboembolic events during warm autoimmune hemolytic anemia

Sylvain Audia et al.

PLOS ONE (2018)

Review Immunology

Venous thromboembolism related to warm autoimmune hemolytic anemia: A case-control study

M. Lecouffe-Desprets et al.

AUTOIMMUNITY REVIEWS (2015)

Article Hematology

Autoimmune hemolytic anemia and venous thromboembolism: A systematic review and meta-analysis

Patompong Ungprasert et al.

THROMBOSIS RESEARCH (2015)

Article Public, Environmental & Occupational Health

Competing risks in epidemiology: possibilities and pitfalls

Per Kragh Andersen et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2012)