4.5 Review

Optimize Local Therapy for Oligometastatic and Oligoprogressive Non-Small Cell Lung Cancer to Enhance Survival

Related references

Note: Only part of the references are listed.
Article Oncology

American Radium Society Appropriate Use Criteria for Radiation Therapy in Oligometastatic or Oligoprogressive Non-Small Cell Lung Cancer

Arya Amini et al.

Summary: Recent studies have shown that the addition of stereotactic body radiation therapy (SBRT) may improve outcomes for patients with oligometastatic non-small cell lung cancer. However, due to limited data, individualized management and multidisciplinary discussions are needed for treating oligometastatic disease.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Review Oncology

Use of Multi-Site Radiation Therapy for Systemic Disease Control

Roshal R. Patel et al.

Summary: This article discusses the potential benefits of using radiation therapy for polymetastatic cancer, proposing a framework for patient selection and highlighting potential challenges. High-dose and low-dose radiation therapy have different applications in oligometastatic and polymetastatic disease. Challenges such as treatment planning workflows, treatment times, dose constraints, and economic considerations are addressed in using radiation therapy for polymetastatic disease.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Article Oncology

Increased biologically effective dose (BED) to the primary tumor is associated with improved survival in patients with oligometastatic NSCLC

Ahsan Farooqi et al.

Summary: This study investigated the impact of the biologically effective dose (BED) of consolidative radiation therapy on local control, progression-free survival (PFS), and overall survival (OS) in oligometastatic non-small cell lung cancer patients. Results showed that delivering >75 Gy BED RT to the primary lesion was associated with improved local control, PFS, and OS. These findings support recent prospective trials and ongoing efforts to characterize the therapeutic benefits of this management strategy.

RADIOTHERAPY AND ONCOLOGY (2021)

Article Oncology

High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: Results of a phase II trial

Roshal R. Patel et al.

Summary: Early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or without low-dose RT (LD-RT) for metastatic cancer showed that the combination of HD-RT plus LD-RT safely improved lesion-specific response by promoting infiltration of effector immune cells into the tumor microenvironment, providing potential benefit for immune resistant solid tumors.

RADIOTHERAPY AND ONCOLOGY (2021)

Article Oncology

Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer

Kewen He et al.

Summary: Multiple rounds of radiation therapy may provide greater clinical benefit by enhancing the adaptive immune response through repeated exposure to tumor antigens released by pulsed radiation therapy.

FRONTIERS IN ONCOLOGY (2021)

Article Critical Care Medicine

Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials

Willemijn S M E Theelen et al.

Lancet Respiratory Medicine (2020)

Article Oncology

Time to abandon single-site irradiation for inducing abscopal effects

Eric D. Brooks et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Immunology

Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment

Hari Menon et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Oncology

Safety of Combined Immunotherapy and Thoracic Radiation Therapy: Analysis of 3 Single-Institutional Phase I/II Trials

Vivek Verma et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

Article Medicine, General & Internal

Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer

L. Gandhi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer

T. S. Mok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Claire Vanpouille-Box et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?

Michael B. Bernstein et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs

Abhineet Uppal et al.

CLINICAL & EXPERIMENTAL METASTASIS (2014)

Article Oncology

DESCRIPTIVE ANALYSIS OF OLIGOMETASTATIC LESIONS TREATED WITH CURATIVE-INTENT STEREOTACTIC BODY RADIOTHERAPY

Michael T. Milano et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2008)