Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 128, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2022.105104
Keywords
Hydroxyapatite bioceramic; Silica-based bioglass; Encapsulation; Osteogenesis; Angiogenesis
Funding
- National Key Research and Development Pro-gram of China [2016YFB0700803]
- National Natural Sci-ence Foundation of China [52172280]
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In this research, BG-modified HA bioceramics were prepared using BG sol encapsulated HA powders. The study found that introducing 1 wt% and 3 wt% BG improved the mechanical performance and apatite mineralization activity of HA-based bioceramics, and played an important role in cellular response. The HA-based bioceramics modified with 1 wt% BG showed excellent biological performance and could be a promising material for bone repair.
Although hydroxyapatite (HA) bioceramic has excellent biocompatibility and osteoconductivity, its high chemical stability results in slow degradation which affects osteogenesis, angiogenesis and clinical applications. Silica-based bioglass (BG) with superior biological performance has been introduced into HA bioceramic to overcome this insufficiency; however, the composite bioceramics are usually prepared by traditional mechanical mixture of HA and BG powders, which tremendously weakens their mechanical performance. In this research, BG-modified HA bioceramics were prepared by the use of BG sol encapsulated HA powders. The results showed that introducing 1 and 3 wt% BG allowed the HA-based bioceramics to maintain the high compressive strength (>300 MPa), improved the apatite mineralization activity, and played an important role in cellular response. The bioceramic modified with 1 wt% BG (1BG/HA) remarkably enhanced in vitro cell proliferation, osteogenic and angiogenic activities. This present work provides a new strategy to improve the biological performance of bioceramics and the HA-based bioceramics with 1 wt% BG can be as a promising candidate material for bone repair.
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