One-pot Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones using nano-cellulose/BF3/Fe3O4

3,4-Dihydropyrimidin-2(1H)-one and its derivatives are significant, especially in the pharmaceutical industry. Regarding the significance of the mentioned compounds, in this paper, an efficient method is introduced for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using nano-cellulose/BF3/Fe3O4 as a Lewis acid catalyst. The desired products are obtained via a one-pot, three-component reaction between the aromatic aldehyde, ethyl acetoacetate and urea. The reaction is performed in ethanol as a green, low-cost and commercially available solvent. Short reaction times, high efficiency, room-temperature reaction conditions, the reusability of the catalyst and easy operation are a number of advantages of this method. The catalyst analysis was done by FT-IR, SEM, TEM, XRD, BET, XRF and TGA techniques. All products were characterized by FT-IR and H-1 NMR spectroscopy. In addition, the catalyst showed very good recovery and no loss in the yield was observed after five sequential reactions. [GRAPHICS] .

Automated summary

This paper introduces an efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using nano-cellulose/BF3/Fe3O4 as a catalyst. The method offers advantages such as short reaction times, high efficiency, and room-temperature reaction conditions. The catalyst is characterized by various techniques and exhibits good recovery.