Journal
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
Volume 19, Issue 7, Pages 3043-3056Publisher
SPRINGER
DOI: 10.1007/s13738-022-02513-y
Keywords
5-Fluorouracil; Er3+-doped ZnAl-LDH; Drug delivery system; Fluorescence labeling
Categories
Funding
- National Natural Science Foundation of China [51864033, 21978127]
- National Key Research Development Program of China [2019YFC0605000]
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Er3+-doped zinc-aluminum layered double hydroxide (Er3+-doped ZnAl-LDH) has been studied as a delivery and release system for 5-fluorouracil (5-Fu), an anticancer drug. Successful intercalation of 5-Fu into the interlayer of Er3+-doped ZnAl-LDH was achieved, and the release of 5-Fu was controlled. The near-infrared emissions of Er3+-doped ZnAl-LDH were reduced upon intercalation and recovered after release, suggesting a potential marking technique for drug delivery.
Erbium-doped zinc-aluminum layered double hydroxide (Er3+-doped ZnAl-LDH) with near-infrared emission has been studied as the delivery and release of the 5-fluorouracil (5-Fu) which was an anticancer drug. Compositional and structural analyses reveal that the 5-Fu has been successfully intercalated into the interlayer of Er3+-doped ZnAl-LDH, and the basal spacing of the Er3+-doped LDH varied from 8.78 to 14.32 angstrom after the intercalation of 5-Fu. The release of 5-Fu was controlled in simulated intestinal medium (phosphate buffer solutions with pH 7.4 and 37 celcius). The releasing behavior of 5-Fu showed an initial quick-release followed by a slow-release. What is more, the intercalation of 5-Fu into the Er3+-doped ZnAl-LDH greatly reduced the near-infrared emissions of the Er3+-doped ZnAl-LDH, whereas the near-infrared emissions were recovered after the release of 5-Fu. The change of near-infrared emissions may be a useful technique for marking the delivery and release of 5-Fu at specific sites. Therefore, the Er3+-doped ZnAl-LDH with cheapness, non-toxicity, bio-compatibility, and little damage to biological tissue, may be a promising drug delivery system with marking or labeling function.
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