Inflammation, Aging, and Cardiovascular Disease JACC Review Topic of the Week

Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular disease, the leading causes of death and disability worldwide. The concept of inflamm-aging recognizes that low-grade inflammatory pathways observed in the elderly contribute to CV risk. Understanding the mechanisms that link inflammation and aging could reveal new therapeutic targets and offer options to cope with the growing aging population worldwide. This review reports recent scientific advances in the pathways through which inflamm-aging mediates age-dependent decline in CV function and disease onset and considers critically the translational potential of such concepts into everyday clinical practice. (C) 2022 the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.

Automated summary

Aging and inflammation both play key roles in cardiovascular and cerebrovascular diseases, recognizing the concept of inflamm-aging can lead to new therapeutic targets and options for the growing aging population. This review discusses recent scientific advances in understanding the pathways of inflamm-aging and its potential implications in clinical practice.