Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 144, Issue 12, Pages 5503-5516Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c00084
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Funding
- National Research Foundation of Korea [2020M3A9D8038190, 2020R1A2C1101377, 2016R1A5A1009405, 2020M3A9D8038192, 2020R1A2C3005939]
- KIST Institutional program [2E31130, 2Z06270-20-138, 2V08610]
- National Supercomputing Center [KSC-2021-CRE-0160]
- National Research Foundation of Korea [2020R1A2C1101377, 2020R1A2C3005939, 2E31130, 2020M3A9D8038192, 2020M3A9D8038190] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The dynamic behavior of biological nanomachines, controlled by supramolecular recognition, has led to the development of potential therapeutic artificial nanomachines. This study integrates actuatable molecular components into a hierarchical nanomaterial to regulate biological functions in response to external stimuli, providing a strategy for designing biomimetic nanotoxins.
Biological nanomachines, including proteins and nucleic acids whose function is activated by conformational changes, are involved in every biological process, in which their dynamic and responsive behaviors are controlled by supramolecular recognition. The development of artificial nanomachines that mimic the biological functions for potential application as therapeutics is emerging; however, it is still limited to the lower hierarchical level of the molecular components. In this work, we report a synthetic machinery nanostructure in which actuatable molecular components are integrated into a hierarchical nanomaterial in response to external stimuli to regulate biological functions. Two nanometers core-sized gold nanoparticles are covered with ligand layers as actuatable components, whose folding/unfolding motional response to the cellular environment enables the direct penetration of the nanoparticles across the cellular membrane to disrupt intracellular organelles. Furthermore, the pH-responsive conformational movements of the molecular components can induce the apoptosis of cancer cells. This strategy based on the mechanical motion of molecular components on a hierarchical nanocluster would be useful to design biomimetic nanotoxins.
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