4.8 Article

Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

Drug delivery systems for RNA therapeutics

Kalina Paunovska et al.

Summary: This article provides an overview of the importance of RNA-based gene therapy and describes the molecular mechanisms of RNA therapies and different drug delivery systems. It also discusses the path from preclinical research to clinical approval for these therapies.

NATURE REVIEWS GENETICS (2022)

Article Multidisciplinary Sciences

Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2

Rodolfo E. De La Vega et al.

Summary: An innovative approach using chemically modified messenger RNA was explored for bone regeneration, showing superior efficacy compared to traditional recombinant human bone morphogenetic protein-2 method, with faster healing speed.

SCIENCE ADVANCES (2022)

Review Engineering, Biomedical

Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges

Xin Gao et al.

Summary: This review focuses on the principles and methods in the design of targeted nanoparticles for the diagnosis and therapy of orthotopic and metastatic bone tumors. Various ligands have been grafted on nanoparticles for bone targeting, and different targeting strategies using monoclonal antibodies, peptides, and aptamers have been explored for diagnosis and therapy. The development of multifunctional nanoparticles to disrupt the vicious cycle between tumor cell proliferation and bone resorption, as well as the challenges and perspectives in this area, are also discussed.

BIOMATERIALS (2021)

Article Multidisciplinary Sciences

Ionizable lipid nanoparticles for in utero mRNA delivery

Rachel S. Riley et al.

Summary: Using ionizable lipid nanoparticles, mRNA can be effectively and safely delivered to mouse fetuses to produce therapeutic secreted proteins, providing a platform for prenatal gene editing and protein replacement.

SCIENCE ADVANCES (2021)

Article Multidisciplinary Sciences

An ionizable lipid toolbox for RNA delivery

Xuexiang Han et al.

Summary: In recent years, RNA therapeutics has seen significant growth, largely due to decades of research on lipid nanoparticles, particularly its key component - ionizable lipid. This commentary discusses the major types of ionizable lipids and offers perspectives for future development.

NATURE COMMUNICATIONS (2021)

Review Oncology

Novel approaches to target the microenvironment of bone metastasis

Lorenz C. Hofbauer et al.

Summary: Bone metastases are a common and severe complication of advanced-stage cancers, particularly in patients with breast and prostate cancer. The interactions between cells in the bone microenvironment affect tumor cell migration, dormancy, and resistance to treatment, and interrupting these interactions can help prevent or treat skeletal metastases.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Chemistry, Multidisciplinary

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

Sarah J. Shepherd et al.

Summary: The study presents a scalable, parallelized microfluidic device (PMD) that can simultaneously operate 128 mixing channels, achieving over 100 times production rate compared to traditional methods for lipid nanoparticles (LNPs). Results demonstrate superior delivery of LNPS generated using PMD in mice, showing potential for emerging clinical applications such as RNA therapeutics and vaccines.

NANO LETTERS (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Article Multidisciplinary Sciences

Harnessing the power of antibodies to fight bone metastasis

Zeru Tian et al.

Summary: The use of bone-targeting technology to chemically couple bisphosphonate compounds to therapeutic antibodies enhances the delivery of conjugates to bone metastatic niches, providing enhanced inhibition of bone and multiorgan secondary metastases. Specific delivery of therapeutic antibodies to the bone represents a promising strategy for the treatment of bone metastatic cancers and other bone diseases.

SCIENCE ADVANCES (2021)

Review Chemistry, Multidisciplinary

Recent advances in bone-targeting nanoparticles for biomedical applications

Xue Zhou et al.

Summary: With the increasing global population aging, the incidence of bone-related diseases has significantly increased, making nanomaterials a research hotspot for treating these diseases. This review summarizes the latest advances in bone-targeting nanoparticles, including classification, mechanisms, and applications, providing direction for future research.

MATERIALS CHEMISTRY FRONTIERS (2021)

Article Chemistry, Multidisciplinary

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

Srinivas Ramishetti et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Margaret M. Billingsley et al.

NANO LETTERS (2020)

Review Pharmacology & Pharmacy

Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes

Nuphar Veiga et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Nanoscience & Nanotechnology

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing

Qiang Cheng et al.

NATURE NANOTECHNOLOGY (2020)

Article Engineering, Biomedical

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Marvin Krohn-Grimberghe et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Review Biochemistry & Molecular Biology

Therapeutic siRNA: state of the art

Bo Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Review Chemistry, Multidisciplinary

Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses

Pedro Lavrador et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Nanoscience & Nanotechnology

A modular platform for targeted RNAi therapeutics

Ranit Kedmi et al.

NATURE NANOTECHNOLOGY (2018)

Review Materials Science, Biomaterials

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Tinke-Marie De Witte et al.

REGENERATIVE BIOMATERIALS (2018)

Article Chemistry, Multidisciplinary

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

Jason B. Miller et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

Matthias A. Oberli et al.

NANO LETTERS (2017)

Review Pharmacology & Pharmacy

Targeted delivery to bone and mineral deposits using bisphosphonate ligands

Lisa E. Cole et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Chemistry, Multidisciplinary

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Quanyin Hu et al.

ADVANCED MATERIALS (2016)

Review Chemistry, Physical

Composite Hydrogels for Bone Regeneration

Gianluca Tozzi et al.

MATERIALS (2016)

Review Immunology

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

Larisa V. Kovtonyuk et al.

FRONTIERS IN IMMUNOLOGY (2016)

Review Oncology

Bone metastasis: the importance of the neighbourhood

Peter I. Croucher et al.

NATURE REVIEWS CANCER (2016)

Review Pharmacology & Pharmacy

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

Yunching Chen et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Article Chemistry, Multidisciplinary

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Review Immunology

Targeting the bone marrow microenvironment in multiple myeloma

Yawara Kawano et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Biotechnology & Applied Microbiology

mRNA-based therapeutics - developing a new class of drugs

Ugur Sahin et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Multidisciplinary Sciences

Engineered nanomedicine for myeloma and bone microenvironment targeting

Archana Swami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell & Tissue Engineering

Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells

Feng-Juan Lv et al.

STEM CELLS (2014)

Article Multidisciplinary Sciences

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Kathryn A. Whitehead et al.

NATURE COMMUNICATIONS (2014)

Review Pharmacology & Pharmacy

Liposomal drug delivery systems: From concept to clinical applications

Theresa M. Allen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Review Chemistry, Multidisciplinary

Biomedical applications of bisphosphonates

Elisabeth V. Giger et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Article Chemistry, Multidisciplinary

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

Muthusamy Jayaraman et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Chemistry, Multidisciplinary

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

Delai Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Immunology

The bone marrow at the crossroads of blood and immunity

Francois E. Mercier et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Review Medicine, General & Internal

Effects of inflammatory and anti-inflammatory cytokines on the bone

Georg Schett

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Chemistry, Multidisciplinary

Gene delivery with bisphosphonate-stabilized calcium phosphate nanoparticles

Elisabeth V. Giger et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Biotechnology & Applied Microbiology

Therapeutic siRNA silencing in inflammatory monocytes in mice

Florian Leuschner et al.

NATURE BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

Rational design of cationic lipids for siRNA delivery

Sean C. Semple et al.

NATURE BIOTECHNOLOGY (2010)

Review Oncology

Future directions of bone-targeted therapy for metastatic breast cancer

Tomifumi Onishi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Article Multidisciplinary Sciences

Lipid-like materials for low-dose, in vivo gene silencing

Kevin T. Love et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Pharmacology & Pharmacy

Organic-Inorganic Composites for Bone Drug Delivery

Chidambaram Soundrapandian et al.

AAPS PHARMSCITECH (2009)

Review Materials Science, Biomaterials

Local antibiotic delivery systems for the treatment of osteomyelitis - A review

Samit Kumar Nandi et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2009)

Review Biotechnology & Applied Microbiology

Knocking down barriers: advances in siRNA delivery

Kathryn A. Whitehead et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biotechnology & Applied Microbiology

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc et al.

NATURE BIOTECHNOLOGY (2008)

Article Biochemistry & Molecular Biology

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Benedetto Sacchetti et al.

Article Dentistry, Oral Surgery & Medicine

Resolution of bisphosphonate-associated osteonecrosis of the mandible: Possible application for intermittent low-dose parathyroid hormone [rhPTH(1-34)]

Richard P. Harper et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2007)

Article Engineering, Biomedical

Electrospun silk-BMP-2 scaffolds for bone tissue engineering

CM Li et al.

BIOMATERIALS (2006)

Article Orthopedics

Local antibiotic delivery vehicles in the treatment of musculoskeletal infection

AD Hanssen

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2005)

Article Endocrinology & Metabolism

Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration

YC Huang et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2005)

Review Microbiology

Studying plasmid horizontal transfer in situ: A critical review

SJ Sorensen et al.

NATURE REVIEWS MICROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

Molecular recognition of BMP-2 and BMP receptor IA

S Keller et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Biotechnology & Applied Microbiology

Bone marrow-derived stem cells initiate pancreatic regeneration

D Hess et al.

NATURE BIOTECHNOLOGY (2003)

Review Biochemistry & Molecular Biology

Gene therapy progress and prospects: Nonviral vectors

T Niidome et al.

GENE THERAPY (2002)

Review Chemistry, Multidisciplinary

Growth factor delivery for tissue engineering

JE Babensee et al.

PHARMACEUTICAL RESEARCH (2000)

Review Multidisciplinary Sciences

Therapeutic approaches to bone diseases

GA Rodan et al.

SCIENCE (2000)