Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 125, Issue 8, Pages 1326-1331Publisher
WILEY
DOI: 10.1002/jso.26847
Keywords
CDH1; hereditary cancer; penetrance risk
Funding
- Italian Ministry of Health [GR-2016-02361655]
- Ricerca Corrente
- 5 x 1000 funds
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This article reviews the penetrance risks of gastric, breast, prostate, and colorectal cancers in CDH1 carriers within and outside the familial setting, as well as the best approaches to managing each risk.
Germline CDH1 defects are related with the development of multiple cancers due its pleiotropic nature. These several conditions are associated with various risks of penetrance and with different clinical management strategies. In this clinical review, we described the penetrance risks of gastric, breast, prostate, and colorectal cancers, in CDH1 carriers, within as well as outside the familial setting, and the best approaches to manage each risk, using either prophylactic surgery or surveillance.
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