Journal
CANCER CELL INTERNATIONAL
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12935-014-0147-z
Keywords
CD146/MCAM; Melanoma; Structure; Mechanism; Metastasis; Angiogenesis
Categories
Funding
- Shandong Provincial Natural Science Foundation [ZR2014HP027]
- Linyi Municipal Science and Technology Development Plan [201413014]
- Scientific Research Items of Hei Long-jiang Provincial Health Bureau of China [2013003]
- Scientific Research Fund of the First Affiliated Hospital of Harbin Medical University [2013704]
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Human malignant melanoma is a common primary malignant cutaneous tumour derived from transformed epidermal melanocytes. Patients with melanoma have a high rate of mortality due to resistance to chemotherapeutic drugs, a major obstacle to a successful treatment. Several reports have suggested that CD146 plays an important role as a signalling molecule in human melanoma. This role includes CD146 as a participant in inflammation, differentiation, adhesion, tumourigenicity, metastasis, invasion and angiogenesis among other processes, which suggests that this molecule promotes the progression of human melanoma as a multifaceted regulator. In this article, we explore the effects and corresponding mechanisms with respect to the role of CD146/MUC18 in the promotion of human melanoma progression. Collectively, the studies indicated that targeting CD146, because it is a suitable marker of poor patient outcome, might be useful in the design of future strategies for the prevention and treatment of human melanoma.
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