被撤回的出版物: Two polyoxometalate-based complexes: Application values on tuberculosis care through increasing antibacterial response of macrophages (Retracted article. See vol. 320, 2023)

The current research reports the synthesis, crystal structures and bioactivity determination of two polyoxometalate-based coordination complexes. By adjusting the distance of the ligands, two Anderson-type polyoxometalate-based metal-pyrazinamide hybrid with the compositions of {HZn(L1)[AlMo6(OH)6O18]}center dot 4H2O (1), {HZn(L2) (H2O)2[AlMo6(OH)6O18]}center dot 4H2O (2) (L1 = N,N0-bis(2-pyrazinecarboxamide)-1,2-ethane, L2 = N,N0- bis(2-pyrazinecarboxamide)-1,4-butane) were formed via hydrothermal conditions, and studied by the single crystal X-ray diffraction analysis and elemental analysis. Their application values on Tuberculosis care were evaluated and the detail mechanism was discussed simultaneously. The results of the ELISA proclaimed that compound 1 was more outstanding than compound 2 on reducing the content of inflammatory cytokines delivered into the plasma. The real time RT-PCR suggested that compound 1 could reduce the inflammatory signaling pathway activation, not compound 2. Subsequently, compound 1 had a greater inhibition on the bacterial viability than compound 2. The CFU assay also showed compound 1 had a greater role than compound 2 on reducing the bacterial survival, which was due to the inhibition of compound 1 on the bacterial survival genes expression.

Automated summary

This study reports the synthesis, crystal structures, and bioactivity determination of two polyoxometalate-based coordination complexes. The results show that compound 1 is more effective than compound 2 in reducing the content of inflammatory cytokines, reducing the activation of the inflammatory signaling pathway, and inhibiting bacterial survival.