4.5 Review

Rapid eye movement sleep behaviour disorder: Past, present, and future

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group

Matteo Cesari et al.

Summary: Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM) sleep behavior disorder (RBD). This study addresses the need for comprehensive and unambiguous v-PSG recommendations to diagnose RBD and identify prodromal RBD, aiming to provide objective v-PSG measures and enable future harmonized multicentric studies and clinical trials.

SLEEP (2022)

Article Neurosciences

Rare PSAP Variants and Possible Interaction with GBA in REM Sleep Behavior Disorder

Yuri L. Sosero et al.

Summary: This study found that loss-of-function mutations in the PSAP gene were present in patients with iRBD, and the co-occurrence with GBA variants suggests a potential genetic interaction. These findings may have implications for understanding the prodromal stage of synucleinopathy and the development of Parkinson's disease.

JOURNAL OF PARKINSONS DISEASE (2022)

Article Clinical Neurology

Comprehensive Analysis of Familial Parkinsonism Genes in Rapid-Eye-Movement Sleep Behavior Disorder

Kheireddin Mufti et al.

Summary: The study found no significant role of autosomal dominant and recessive PD or atypical parkinsonism genes in the risk of iRBD. There was no association between rare heterozygous variants in the tested genes and the risk of iRBD. Homozygous and compound heterozygous carriers were not overrepresented in iRBD patients compared to controls.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Zerui Wang et al.

Summary: The study demonstrates that skin alpha Syn(P) seeding activity can potentially serve as a novel biomarker for antemortem diagnosis of Parkinson disease (PD) and other synucleinopathies. The analysis of skin samples from autopsies and biopsies shows a significant increase in alpha Syn(P) seeding activity in individuals with PD and synucleinopathies compared to controls with tauopathies and non-neurodegenerative diseases.

JAMA NEUROLOGY (2021)

Article Neurosciences

A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice

Shuntaro Uchida et al.

Summary: This study identified a specific subpopulation of Gly(VMM) neurons in the ventromedial medulla that are involved in generating muscle atonia during REM sleep. Silencing this circuit resulted in REM sleep without muscle atonia and reduced time spent in cataplexy-like episodes. Additionally, Gly(VMM) neurons also play a crucial role in maintaining sleep and cataplexy.

JOURNAL OF NEUROSCIENCE (2021)

Article Clinical Neurology

Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder

Kheireddin Mufti et al.

Summary: Rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Further studies are needed to confirm these findings and explore the potential of targeting BST1 loss of function as a therapeutic approach.

NEUROLOGY (2021)

Article Clinical Neurology

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Alex Iranzo et al.

Summary: The study found that RT-QuIC can detect misfolded alpha-synuclein in the CSF of patients with IRBD with both high sensitivity and specificity, indicating that detection of alpha-synuclein may serve as an early marker for Parkinson's disease and dementia with Lewy bodies.

LANCET NEUROLOGY (2021)

Article Genetics & Heredity

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Ruth Chia et al.

Summary: By conducting whole-genome sequencing and genetic analysis, researchers have identified common genetic risk factors and pathways shared between Lewy body dementia, Alzheimer's disease, and Parkinson's disease. This provides a deeper understanding of the complex genetic architecture of these age-related neurodegenerative conditions.

NATURE GENETICS (2021)

Article Clinical Neurology

Specialist approaches to prognostic counseling in isolated REM sleep behavior disorder

Luke N. Teigen et al.

Summary: Most expert RBD sleep clinicians routinely provide counseling to their patients regarding the high risk for developing parkinsonism or dementia, but relatively few ask patients about their preferences for receiving this information, and fewer provide details concerning the known high risk estimates for developing a synucleinopathy. Future research should analyze patients' values and preferences in RBD populations to inform approaches toward shared decision making for RBD prognostic counseling.

SLEEP MEDICINE (2021)

Article Clinical Neurology

Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder

Ambra Stefani et al.

Summary: RT-QuIC detection of alpha-synuclein aggregates in olfactory mucosa showed a linkage between alpha-synuclein pathology and olfactory dysfunction in patients with isolated RBD and Parkinson's disease, indicating a potential for early detection and preventive therapies.

BRAIN (2021)

Review Clinical Neurology

Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

Mitchell G. Miglis et al.

Summary: Patients with isolated rapid-eye-movement sleep behavior disorder (RBD) are considered to be in the early stages of progressive neurodegenerative diseases involving alpha-synuclein pathology, such as Parkinson's disease or multiple system atrophy. Developing reliable biomarkers is crucial for predicting disease progression, monitoring treatment response, and predicting the subtype of alpha-synucleinopathy patients with isolated RBD.

LANCET NEUROLOGY (2021)

Article Multidisciplinary Sciences

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy

Mohammad Shahnawaz et al.

NATURE (2020)

Review Clinical Neurology

Clinical trials in REM sleep behavioural disorder: challenges and opportunities

Aleksandar Videnovic et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Article Clinical Neurology

Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

Brit Mollenhauer et al.

MOVEMENT DISORDERS (2020)

Article Clinical Neurology

Glucocerebrosidase mutations and phenoconversion of REM sleep behavior disorder to parkinsonism and dementia

Lucy Honeycutt et al.

PARKINSONISM & RELATED DISORDERS (2019)

Article Clinical Neurology

Clonazepam for probable REM sleep behavior disorder in Parkinson's disease: A randomized placebo-controlled trial

Chaewon Shin et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2019)

Review Clinical Neurology

Idiopathic REM sleep behaviour disorder and neurodegeneration - an update

Birgit Hoegl et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Multidisciplinary Sciences

Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder

Sara Valencia Garcia et al.

NATURE COMMUNICATIONS (2018)

Article Clinical Neurology

Activation of the motor cortex during phasic rapid eye movement sleep

Fabrizio De Carli et al.

ANNALS OF NEUROLOGY (2016)

Article Clinical Neurology

Rapid eye movement sleep behaviour disorder in women with Parkinson's disease is an underdiagnosed entity

Rohan R. Mahale et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2016)

Editorial Material Clinical Neurology

ABSENCE OF LRRK2 MUTATIONS IN A COHORT OF PATIENTS WITH IDIOPATHIC REM SLEEP BEHAVIOR DISORDER

Ruben Fernandez-Santiago et al.

NEUROLOGY (2016)

Review Clinical Neurology

A new view of dream enactment in REM sleep behavior disorder

Mark S. Blumberg et al.

SLEEP MEDICINE REVIEWS (2016)

Article Clinical Neurology

Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder

Carolina Aguirre-Mardones et al.

JOURNAL OF NEUROLOGY (2015)

Article Neurosciences

Sensorimotor Processing in the Newborn Rat Red Nucleus during Active Sleep

Carlos Del Rio-Bermudez et al.

JOURNAL OF NEUROSCIENCE (2015)

Article Neurosciences

Identification of the Transmitter and Receptor Mechanisms Responsible for REM Sleep Paralysis

Patricia L. Brooks et al.

JOURNAL OF NEUROSCIENCE (2012)

Review Clinical Neurology

REM sleep behavior disorder: Motor manifestations and pathophysiology

Isabelle Arnulf

MOVEMENT DISORDERS (2012)

Review Public, Environmental & Occupational Health

Rapid Eye Movement Sleep Behavior Disorder in Women: Relevance to General and Specialty Medical Practice

Cynthia L. Bodkin et al.

JOURNAL OF WOMENS HEALTH (2009)

Article Multidisciplinary Sciences

Localization of the Brainstem GABAergic Neurons Controlling Paradoxical (REM) Sleep

Emilie Sapin et al.

PLOS ONE (2009)

Article Clinical Neurology

Video analysis of motor events in REM sleep behavior disorder

Birgit Frauscher et al.

MOVEMENT DISORDERS (2007)

Article Clinical Neurology

Restoration of normal motor control in Parkinson's disease during REM sleep

Valerie Cochen De Cock et al.

BRAIN (2007)

Article Clinical Neurology

Phenomenology of dreams in Parkinson's disease

Leora L. Borek et al.

MOVEMENT DISORDERS (2007)

Article Clinical Neurology

Sleep and sleep disorders in Don Quixote

A Iranzo et al.

SLEEP MEDICINE (2004)

Article Clinical Neurology

Where does Parkinson disease pathology begin in the brain?

K Del Tredici et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

Review Physiology

Synaptic central of motoneuronal excitability

JC Rekling et al.

PHYSIOLOGICAL REVIEWS (2000)