Dietary Amino Acid Patterns Are Associated With Incidence of Chronic Kidney Disease

Objectives: No findings are available regarding the association of the dietary amino acid (AA) intakes with the risk of chronic kidney disease (CKD) in adults. We aimed to assess the association between dietary AA patterns and incidence of CKD in adults. Design and Methods: This study was conducted within the framework of Tehran Lipid and Glucose Study on 4,233 adults, who were free of CKD at baseline (2009-2011) and were followed for 3.1 years (2011-2014). The principal component analysis was used based on 8 AA groups to characterize major AA patterns. Multivariable logistic regression models were used to estimate the risk of CKD across quartiles of dietary AA pattern scores. Results: Three major AA patterns were extracted: (1) higher loads of branched-chain, alcoholic, and aromatic AAs; (2) higher loads of acidic AAs, proline, and lower load of alkaline AAs and small AAs; and (3) higher loads of sulfuric AAs and small AAs. The mean +/- standard deviation age of participants (45.9% male) was 39.4 +/- 11.7 at baseline and the incidence of CKD was 12.1% (513 cases) after 3.1 years of follow-up. The highest score of first dietary AA pattern tended to be associated with an increased risk of CKD (odds ratio = 1.43, 95% confidence interval 1.06-1.93); however, the second pattern was related to a decreased risk of CKD (odds ratio = 0.71, 95% confidence interval: 0.52-0.97) in the multivariable model. Conclusion: These novel findings suggest that the dietary AA patterns may modify risk of CKD. (C) 2021 by the National Kidney Foundation, Inc. All rights reserved.

Automated summary

This study examined the association between dietary amino acid (AA) patterns and the risk of chronic kidney disease (CKD) in adults. The findings suggest that different AA patterns may modify the risk of CKD, with the first pattern potentially increasing the risk and the second pattern potentially decreasing the risk.