Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 148, Issue -, Pages 293-306Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2022.02.007
Keywords
Depression; Neuroinflammation; miRNAs; lncRNAs; circRNAs
Categories
Funding
- Guangdong Basic and Applied Basic Research Foundation [2021A1515010862]
- Sci-ence and Technology Program of Guangzhou [202102080042]
- Administration of Traditional Chinese Medicine of Guangdong Province [20211020]
- National Natural Science Foundation of China [81671351]
- Science Foundation of Guangdong Second Provincial General Hospital [3D-B2020015]
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The high incidence and relapse rate of depression, as well as its comorbidity with other diseases, have made it one of the primary causes of disability. The role of neuroinflammation in the pathogenesis of depression is significant, affecting various biological processes. Non-coding RNAs may be a breakthrough in understanding the link between depression and neuroinflammation, and they could potentially regulate the occurrence and progression of depression through neuroinflammation.
The high incidence and relapse rate of depression, as well comorbidity with other diseases, has made depression one of the primary causes of years of life lived with disability. Moreover, the unknown biological mechanism of depression has made treatment difficult. Neuroinflammation is important in the pathogenesis of depression. Neuroinflammation may affect depression by regulating the production of immune factors, immune cell activation, neuron generation, synaptic plasticity, and neurotransmission. Non-coding RNAs (ncRNAs) may be a breakthrough link between depression and neuroinflammation, as ncRNAs participate in these biological changes. We summarize the functions and mechanisms of ncRNAs in neuroinflammation and depression, and predict ncRNAs that may regulate the occurrence and progression of depression through neuritis. These findings not only broaden our understanding of the genetic regulation of depression and neuroinflammation but also provide a new perspective of the underlying mechanism and aid in the design of novel prevention, diagnosis, and treatment strategies.
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