A new perspective on depression and neuroinflammation: Non-coding RNA

The high incidence and relapse rate of depression, as well comorbidity with other diseases, has made depression one of the primary causes of years of life lived with disability. Moreover, the unknown biological mechanism of depression has made treatment difficult. Neuroinflammation is important in the pathogenesis of depression. Neuroinflammation may affect depression by regulating the production of immune factors, immune cell activation, neuron generation, synaptic plasticity, and neurotransmission. Non-coding RNAs (ncRNAs) may be a breakthrough link between depression and neuroinflammation, as ncRNAs participate in these biological changes. We summarize the functions and mechanisms of ncRNAs in neuroinflammation and depression, and predict ncRNAs that may regulate the occurrence and progression of depression through neuritis. These findings not only broaden our understanding of the genetic regulation of depression and neuroinflammation but also provide a new perspective of the underlying mechanism and aid in the design of novel prevention, diagnosis, and treatment strategies.

Automated summary

The high incidence and relapse rate of depression, as well as its comorbidity with other diseases, have made it one of the primary causes of disability. The role of neuroinflammation in the pathogenesis of depression is significant, affecting various biological processes. Non-coding RNAs may be a breakthrough in understanding the link between depression and neuroinflammation, and they could potentially regulate the occurrence and progression of depression through neuroinflammation.