Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 50, Issue 4, Pages 1137-1148Publisher
IOS PRESS
DOI: 10.3233/JAD-150989
Keywords
Alzheimer's disease; apolipoprotein E; corpus callosum; functional magnetic resonance imaging; memory
Categories
Funding
- 12th Five-year Plan for National Science and Technology Supporting Program of China [2012BAI10B04]
- National Natural Science Foundation of China [81371519, 81301190]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering
- Abb Vie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd and its affiliatedcompany Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso ScaleDiagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis PharmaceuticalsCorporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
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The apolipoprotein E (APOE) epsilon 4 allele is the best-known genetic risk factor for developing sporadic Alzheimer's disease (AD). According to neuroimaging studies, the APOE epsilon 4 allele is associated with localized altered brain function. However, in long-range circuitry, APOE epsilon 4 allele-related alterations in functional communication between hemispheres have rarely been directly investigated. We examined the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in cognitively intact, elderly APOE epsilon 4 carriers. The voxel-mirrored homotopic connectivity method was used to assess the inter-hemispheric RSFC. The current study included 13 cognitively intact, elderly APOE epsilon 4 carriers (with at least one copy of APOE epsilon 4 allele) and 22 well-matched epsilon 3 homozygotes. Comparisons between the two groups were conducted, and subsequently, the correlation between the differential inter-hemispheric RSFC and cognitive ability was analyzed. Compared with epsilon 3 homozygotes, APOE epsilon 4 carriers showed decreased inter-hemispheric RSFC in the bilateral medial temporal lobe (MTL) and orbital frontal cortex (OFC). Moreover, in APOE epsilon 4 carriers, the inter-hemispheric RSFC of the MTL correlated with the Wechsler Memory Scale-Logical Memory (WMS-LM) (immediate and delayed performance, r = 0.64, p < 0.05; r = 0.65, p < 0.05, respectively), and the inter-hemispheric RSFC of the OFC correlated with the WMS-LM delayed performance (r = 0.71, p < 0.05). In our study, the presence of the APOE epsilon 4 allele was linked with decreased inter-hemispheric RSFC, which was attributed to memory performance in carriers.
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