Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 54, Issue 4, Pages 1607-1618Publisher
IOS PRESS
DOI: 10.3233/JAD-160425
Keywords
Alzheimer's disease; apolipoprotein E; atherosclerosis; cerebral small vessel diseases; neuropathology
Categories
Funding
- Sri Lanka Council for Agricultural Research Policy (CARP Project) [12/684/515]
- Sri Lanka National Science Foundation [RG 2000/M/16]
- University of Sri Jayewardenepura [ASP/06/RE/2010/07]
- University of New South Wales
- International Brain Research Organization-Asia Pacific Regional Committee (IBRO-APRC)
Ask authors/readers for more resources
Background: Evidence from various consortia on vascular contributions has been inconsistent in determining the etiology of sporadic Alzheimer's disease (AD). Objective: To investigate vascular risk factors and cerebrovascular pathologies associated in manifestation of AD-related neuropathological changes of an elderly population. Methods: Postmortem brain samples from 76 elderly subjects (>= 50 years) were used to study genetic polymorphisms, intracranial atherosclerosis of the circle of Willis (IASCW), and microscopic infarcts in deep white matters. From this cohort, 50 brains (>= 60 years) were subjected to neuropathological diagnosis using immunohistopathological techniques. Results: Besides the association with age, the apolipoprotein E epsilon 4 allele was significantly and strongly associated with Thal amyloid-beta phases >= 1 [odds ratio (OR) = 6.76, 95% confidence interval (CI) 1.37-33.45] and inversely with Braak neurofibrillary tangle (NFT) stages >= III (0.02, 0.0-0.47). Illiterates showed a significant positive association for Braak NFT stages >= IV (14.62, 1.21-176.73) and a significant negative association for microscopic infarcts (0.15, 0.03-0.71) in deep white matters. With respect to cerebrovascular pathologies, cerebral small vessel lesions (white matter hyperintensities and cerebral amyloid angiopathy) showed a higher degree of associations among them and with AD-related neuropathological changes (p < 0.05) compared to large vessel pathology (IASCW), which showed a significant association only with Braak NFT stages >= I (p = 0.050). Conclusion: These findings suggest that besides age, education, and genetic factors, other vascular risk factors were not associated with AD-related neuropathological changes and urge prompt actions be taken against cerebral small vessel diseases since evidence for effective prevention is still lacking.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available