4.6 Review

Exercise, healthy ageing, and the potential role of small extracellular vesicles

Related references

Note: Only part of the references are listed.
Article Cell Biology

Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo

Andrea L. Estrada et al.

Summary: This study found that skeletal muscle tissue secretes more extracellular vesicles (EVs) compared to white adipose tissue (WAT), and a significant proportion of EVs from skeletal muscle tissue are derived from myofibers. Furthermore, it was shown that these myofiber-derived EVs can reach the circulation in vivo.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

Review Neurosciences

The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise

Ivan J. Vechetti et al.

Summary: Regular exercise plays a crucial role in reducing the risk of certain diseases. Skeletal muscle-specific cytokines and extracellular vesicles released during exercise may contribute to the positive effects on metabolism. Research on the potential role of EVs in muscle and systemic adaptation to exercise has generated interest in various fields.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Article Cell Biology

Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Lei Zhang et al.

Summary: Inhibiting NF-κ B activation with SR12343 shows promising results in reducing cellular senescence markers, improving muscle fiber size, and extending healthy lifespan. The therapeutic effects of SR12343 were observed in different mouse models, suggesting it as a potential treatment for reducing cellular senescence and aging-related diseases.

AGING CELL (2021)

Review Cell Biology

Is exercise a senolytic medicine? A systematic review

Xiang-Ke Chen et al.

Summary: The study on the senolytic effects of exercise or physical activity reveals that exercise has senolytic properties under certain conditions, warranting further investigation.

AGING CELL (2021)

Article Biochemistry & Molecular Biology

SOD1, more than just an antioxidant

Elis Cristina Araujo Eleutherio et al.

Summary: During cellular respiration, radicals like superoxide can cause cell damage, but cells use the enzyme Cu/Zn Superoxide Dismutase (SOD1) to convert superoxide into oxygen and hydrogen peroxide. In addition to its primary function, SOD1 also plays other roles, such as activating gene transcription or functioning as an RNA binding protein.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Review Biochemical Research Methods

Advances and Utility of the Human Plasma Proteome

Eric W. Deutsch et al.

Summary: The study of proteins circulating in blood presents significant opportunities for diagnosing, stratifying, or preventing diseases. Recent technological advancements have made the proteomic analysis of blood-derived serum and plasma increasingly important in understanding human biology and pathophysiology. By utilizing mass-spectrometry (MS) or affinity-based methods, valuable insights into SARS-CoV-2 infections, aging, and hemostasis have been gained, along with the potential to combine proteomics with genetic data for further insights. The ongoing challenges include translating plasma proteomics into precision medicine, with recent advances in the field providing impactful applications.

JOURNAL OF PROTEOME RESEARCH (2021)

Article Cell Biology

Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence-associated secretory phenotype

Ryan Wallis et al.

Summary: The secretion of small extracellular vesicles (EVs) by senescent cells is found to play an important role in aging and age-related pathologies. Separating the soluble SASP from the vesicular component helps clarify the functional significance of EVs and provides a framework for future investigations.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Review Cell Biology

Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Samuel Darkwah et al.

Summary: EVs play a key role in intercellular communication, with muscle cell-derived EVs potentially modulating organ remodeling by carrying myokines and other substances, contributing to the establishment and modulation of pre-metastatic niches in vital sites for metastatic tumors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

Akaitz Dorronsoro et al.

Summary: The injection of BM-MSCs from young mice can prolong lifespan and healthspan, while conditioned media (CM) from young BM-MSCs can rescue the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM can extend lifespan in mice, and EVs from MSCs generated from human ES cells can reduce senescence and improve healthspan.

AGING CELL (2021)

Article Multidisciplinary Sciences

Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males

Maria Apostolopoulou et al.

Summary: The study found that 12 weeks of high-intensity interval training can improve insulin sensitivity in males, but individuals with insulin resistance showed different alterations in metabolism and inflammatory signals. Changes in the proteome of SEVs might influence the metabolic response to exercise training in humans.

SCIENCE ADVANCES (2021)

Article Cell Biology

NF-κB/IKK activation by small extracellular vesicles within the SASP

Juan Antonio Fafian-Labora et al.

Summary: The study showed that IKK epsilon, IKK alpha, and IKK beta play crucial roles in EV-mediated senescence, while siRNA targeting p65 can prevent senescence activation. Additionally, the IKK pathways are also relevant to aging, as knockout of IKKA, IKKB, and IKKE can avoid the activation of senescence.

AGING CELL (2021)

Article Cell Biology

Exercise reduces circulating biomarkers of cellular senescence in humans

Davis A. Englund et al.

Summary: This study demonstrates that a 12-week structured exercise program significantly improves physical function in older adults, while reducing the expression of key markers of the senescence program and circulating concentrations of senescence-related proteins. Levels of senescence-related proteins at baseline are predictive of changes in physical function in response to the exercise intervention.

AGING CELL (2021)

Article Cell Biology

Discovery of thymosin β4 as a human exerkine and growth factor

Alba Gonzalez-Franquesa et al.

Summary: TMSB4X is identified as an upregulated secreted protein during exercise, with potential effects on osteoblast proliferation and neurite outgrowth, but does not ameliorate metabolic disruptions associated with obesity or enhance muscle regeneration.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

Article Physiology

Extracellular vesicles released from stress-induced prematurely senescent myoblasts impair endothelial function and proliferation

Zachary R. Hettinger et al.

Summary: The study found that stress-induced premature senescence increased the release of extracellular vesicles from myoblasts, which in turn impaired endothelial cell function. The findings highlight the potential impact of senescence on cellular microenvironment and communication between cells.

EXPERIMENTAL PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis

Ivan J. Vechetti et al.

Summary: Regular physical activity may improve health by releasing factors from skeletal muscle through extracellular vesicles (EVs) containing miR-1, promoting adipose tissue metabolic adaptations. EVs are preferentially taken up by eWAT, enhancing adrenergic signaling and lipolysis, ultimately benefiting overall health.

FASEB JOURNAL (2021)

Article Cell Biology

Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker

Fernanda G. Kugeratski et al.

Summary: The study used an unbiased and quantitative proteomic approach to identify core constituents of exosomes, with syntenin-1 identified as a potential universal biomarker. A comprehensive quantitative atlas of core proteins ubiquitous to exosomes was provided, highlighting the potential use of syntenin-1 as a putative universal biomarker for exosomes.

NATURE CELL BIOLOGY (2021)

Article Biochemical Research Methods

A size-exclusion-based approach for purifying extracellular vesicles from human plasma

Patrick M. Vanderboom et al.

Summary: This study introduces a SEC-MS method for purifying EVs from plasma and identifying tissue-specific EV markers, as well as evaluating the effects of exercise on EV proteomic cargo in human plasma.

CELL REPORTS METHODS (2021)

Article Biochemistry & Molecular Biology

The ProteomeXchange consortium in 2020: enabling 'big data' approaches in proteomics

Eric W. Deutsch et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

Review Biochemical Research Methods

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

Nathan Basisty et al.

EXPERT REVIEW OF PROTEOMICS (2020)

Article Biochemical Research Methods

Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification

Anton Iliuk et al.

JOURNAL OF PROTEOME RESEARCH (2020)

Editorial Material Biochemistry & Molecular Biology

SnapShot: Extracellular Vesicles

Federico Cocozza et al.

Article Cell Biology

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage

Juan Antonio Fafian-Labora et al.

CELL METABOLISM (2020)

Review Biochemistry & Molecular Biology

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice

Sathyaseelan S. Deepa et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Geriatrics & Gerontology

Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength

Hye-Na Cha et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

Article Cell Biology

Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

Mitsukuni Yoshida et al.

CELL METABOLISM (2019)

Review Cell Biology

Microvesicles: ROS scavengers and ROS producers

G. Bodega et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

Article Medicine, Research & Experimental

Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies

Philipp E. Geyer et al.

EMBO MOLECULAR MEDICINE (2019)

Review Physiology

Skeletal Muscle-Released Extracellular Vesicles: State of the Art

Sophie Rome et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Article Biochemical Research Methods

Redefining Tissue Crosstalk via Shotgun Proteomic Analyses of Plasma Extracellular Vesicles

Martin Whitham et al.

PROTEOMICS (2019)

Article Medicine, Research & Experimental

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise

Adeel Safdar et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Article Cell Biology

Aged cells in human skeletal muscle after resistance exercise

Chi Yang et al.

AGING-US (2018)

Article Cell Biology

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

Martin Whitham et al.

CELL METABOLISM (2018)

Article Biochemistry & Molecular Biology

Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation

Jung-Hak Kim et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Review Medicine, Research & Experimental

Mechanisms and functions of cellular senescence

Nicolas Herranz et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

Chi Kwan Tsang et al.

MOLECULAR CELL (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemical Research Methods

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van Deun et al.

NATURE METHODS (2017)

Review Cell Biology

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

Sybren L. N. Maas et al.

TRENDS IN CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Masaki Takasugi et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence

Young-Ho Park et al.

BMB REPORTS (2017)

Article Cell Biology

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane

Kerstin Menck et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

Review Neurosciences

Exercise-induced oxidative stress: past, present and future

Scott K. Powers et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Review Multidisciplinary Sciences

Mass-spectrometric exploration of proteome structure and function

Ruedi Aebersold et al.

NATURE (2016)

Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Multidisciplinary Sciences

G6PD protects from oxidative damage and improves healthspan in mice

Sandrina Nobrega-Pereira et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Monitoring changes in thioredoxin and over-oxidised peroxiredoxin in response to exercise in humans

A. J. Wadley et al.

FREE RADICAL RESEARCH (2015)

Review Biochemistry & Molecular Biology

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Bennett G. Childs et al.

NATURE MEDICINE (2015)

Review Oncology

Forging a signature of in vivo senescence

Norman E. Sharpless et al.

NATURE REVIEWS CANCER (2015)

Article Cell Biology

Physical exercise induces rapid release of small extracellular vesicles into the circulation

Carsten Fruehbeis et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Article Biochemistry & Molecular Biology

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Saul A. Villeda et al.

NATURE MEDICINE (2014)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

Article Geriatrics & Gerontology

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

Viviana I. Perez et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2011)

Article Multidisciplinary Sciences

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Saul A. Villeda et al.

NATURE (2011)

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts

Jennifer J. Young et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Multidisciplinary Sciences

A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance

Monika Olahova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence

YH Han et al.

FEBS LETTERS (2005)