Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 53, Issue 3, Pages 981-989Publisher
IOS PRESS
DOI: 10.3233/JAD-150862
Keywords
Association; cognitive impairment; dementia; gene; meta-analysis; vascular
Categories
Funding
- Alzheimer's Society (UK) [Ref117]
- Sigmund Gestetner Foundation
- BRACE (Bristol Research into Alzheimer's and Care of the Elderly)
- Brains for Dementia Research
- Medical Research Council
- Wellcome Trust
- MRC
- Alzheimer's Research UK (ARUK)
- Welsh Assembly Government
- Alzheimer's Society
- Ulster Garden Villages
- N. Ireland RD Office
- Royal College of Physicians/Dunhill Medical Trust
- Mercer's Institute for Research on Ageing
- Bristol Research into Alzheimer's care of the Elderly
- Charles Wolfson Charitable Trust
- NIH
- Barnes Jewish Foundation
- Charles and Joanne Knight Alzheimer's Research Initiative
- UCLH/UCL Biomedical Centre
- Lundbeck SA
- German Federal Ministry of Education and Research (BMBF), Competence Network Dementia
- Alfried Krupp von Bohlen und Halbach-Stiftung
- German Federal Ministry of Education and Research (BMBF), Competence Network Degenerative Dementia
- UK MRC [G0400074]
- Newcastle NIHR Biomedical Research Centre in Ageing and Age Related Diseases
- ARUK as part of the Brains for Dementia Research Project
- NIHR Biomedical Research Centre Programme, Oxford
- MRC [G0502157, G0900652, G0400074, G0500247, G1100540, MC_PC_14095] Funding Source: UKRI
- Medical Research Council [G0500247, G0400074, G1100540, G0900652, G0502157, MC_PC_14095] Funding Source: researchfish
- Alzheimer"
- s Society [117] Funding Source: researchfish
Ask authors/readers for more resources
Vascular cognitive impairment (VCI), including its severe form, vascular dementia (VaD), is the second most common form of dementia. The genetic etiology of sporadic VCI remains largely unknown. We previously conducted a systematic review and meta-analysis of all published genetic association studies of sporadic VCI prior to 6 July 2012, which demonstrated that APOE (epsilon 4, epsilon 2) and MTHFR (rs1801133) variants were associated with susceptibility for VCI. De novo genotyping was conducted in a new independent relatively large collaborative European cohort of VaD (n(max) = 549) and elderly non-demented samples (n(max) = 552). Where available, genotype data derived from Illumina's 610-quad array for 1210 GERAD1 control samples were also included in analyses of genes examined. Associations were tested using the Cochran-Armitage trend test: MTHFR rs1801133 (OR = 1.36, 95% CI 1.16-1.58, p = < 0.0001), APOE rs7412 (OR = 0.62, 95% CI 0.42-0.90, p = 0.01), and APOE rs429358 (OR = 1.59, 95% CI 1.17-2.16, p = 0.003). Association was also observed with APOE epsilon alleles; epsilon 4 (OR = 1.85, 95% CI 1.35-2.52, p = < 0.0001) and epsilon 2 (OR = 0.67, 95% CI 0.46-0.98, p = 0.03). Logistic regression and Bonferroni correction in a subgroup of the cohort adjusted for gender, age, and population maintained the association of APOE rs429358 and epsilon 4 allele.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available