Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 55, Issue 2, Pages 797-811Publisher
IOS PRESS
DOI: 10.3233/JAD-160289
Keywords
Aerosol; amyloid-beta; curcumin; nebulization
Categories
Funding
- National Institutes of Health [R01CA16700]
- VICC Cancer Center Support grant
- National Center for Research Resources [UL1 RR024975-01]
- National Center for Advancing Translational Sciences [2 UL1 TR000445-06]
- Vanderbilt-Ingram Cancer Center Thoracic Program Initiative
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We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.
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