Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 428, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2022.113882
Keywords
Zn2+; Hg2+; Chemosensor; Thiourea; Bio-imaging; Desulfurization
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Funding
- National Research Foundation of Korea (NRF) [2018R1A2B6001686]
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A new fluorescent chemosensor NTHC was synthesized, which can selectively sense Hg2+ and Zn2+ ions and be applied for the bioimaging of zinc in zebrafish.
A new thiophene-and thiourea-based fluorescent chemosensor NTHC, N-(naphthalen-1-yl)-2-(thiophene-2carbonyl)hydrazine-1-carbothioamide, was synthesized. NTHC can operate as a dual-functional chemosensor for selective sensing of Hg2+ and Zn2+ by fluorescent turn-on in different solvents, bis-tris buffer, and aqueous DMSO. According to the analysis of Job plot and ESI-mass, the complexation mode of NTHC to Zn2+ was determined to be a 1:1 ratio. The limits of detection of Hg2+ and Zn2+ turned out to be 4.92 mu M and 3.17 mu M, respectively. Interestingly, NTHC detected Hg2+ via the mercury-promoted desulfurization reaction of thiourea to urea. Moreover, NTHC can be applied for the bioimaging of zinc in zebrafish. The bioimaging showed fluorescence in air bladder and eyes of zebrafish. The binding mechanisms of NTHC with the two ions were identified by Job plot analysis, ESI-mass, DFT calculations, and NMR titration.
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