4.5 Article

Fate Determination Role of Erythropoietin and Romiplostim in the Lineage Commitment of Hematopoietic Progenitors

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

A quantitative systems pharmacology model of hyporesponsiveness to erythropoietin in rats

Ly Minh Nguyen et al.

Summary: A quantitative systems pharmacology (QSP) model was developed to study hyporesponsiveness to rHuEPO in rats. The study found that negative feedback regulation, neocytolysis, and depletion of erythroid precursors are major factors leading to hyporesponsiveness. The model adequately characterizes time courses of rHuEPO PK and nine PD endpoints in both control and treatment groups.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2021)

Review Hematology

Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants

Nayoung Kwon et al.

Summary: This review provides insights into our current understanding of fate decisions in bipotent megakaryocyte-erythroid progenitors (MEPs), discussing isolation of primary human MEP, gene expression patterns, transcription factors, and external factors involved in MEP fate determination, with an overview of debates in the field. Understanding MEP fate is crucial for studying diseases like anemia and leukemia, and MEP also serve as a model system for studying cell fate decisions, applicable to stem/progenitor cell biology.

CURRENT OPINION IN HEMATOLOGY (2021)

Article Pharmacology & Pharmacy

Pharmacodynamic Drug-Drug Interactions

Jin Niu et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

Article Hematology

Rats provide a superior model of human stress erythropoiesis

Jingxin Zhang et al.

EXPERIMENTAL HEMATOLOGY (2019)

Article Physiology

Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease

Jiu-Hong Li et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2019)

Article Multidisciplinary Sciences

A novel approach to adenine-induced chronic kidney disease associated anemia in rodents

Asadur Rahman et al.

PLOS ONE (2018)

Review Cell & Tissue Engineering

Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies

Juliana Xavier-Ferrucio et al.

STEM CELLS (2018)

Article Pharmacology & Pharmacy

Dynamics of Erythropoietic Biomarkers in Response to Treatment With Erythropoietin in Belgrade Rats

Ly M. Nguyen et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Cell & Tissue Engineering

Large-Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells

Yu Zhang et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Article Critical Care Medicine

Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress

Amy V. Gore et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2015)

Review Biochemistry & Molecular Biology

Anemia: progress in molecular mechanisms and therapies

Vijay G. Sankaran et al.

NATURE MEDICINE (2015)

Article Critical Care Medicine

Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress

Amy V. Gore et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2015)

Review Pharmacology & Pharmacy

Analysis of drug combinations: current methodological landscape

Julie Foucquier et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2015)

Article Immunology

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

Amit Grover et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Medicine, Research & Experimental

L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats

Eylem Taskin

MEDICAL SCIENCE MONITOR (2014)

Article Chemistry, Multidisciplinary

Erythropoietin-Induced Erythroid Precursor Pool Depletion Causes Erythropoietin Hyporesponsiveness

Xiaoyu Yan et al.

PHARMACEUTICAL RESEARCH (2013)

Article Chemistry, Multidisciplinary

Pharmacokinetic and Pharmacodynamic Modeling of Romiplostim in Animals

Wojciech Krzyzanski et al.

PHARMACEUTICAL RESEARCH (2013)

Article Pharmacology & Pharmacy

Simultaneous Pharmacokinetics/Pharmacodynamics Modeling of Recombinant Human Erythropoietin upon Multiple Intravenous Dosing in Rats

Sihem Ait-Oudhia et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Review Hematology

Current status of thrombopoietic agents

Elizabeth Rhodes et al.

EXPERT REVIEW OF HEMATOLOGY (2010)

Article Pharmacology & Pharmacy

Pharmacokinetics and Pharmacodynamics of the Erythropoietin Mimetibody (TM) Construct CNTO 528 in Healthy Subjects

Juan Jose Perez-Ruixo et al.

CLINICAL PHARMACOKINETICS (2009)

Article Urology & Nephrology

Neutrophil activation and resistance to recombinant human erythropoietin therapy in hemodialysis patients

Elisio Costa et al.

AMERICAN JOURNAL OF NEPHROLOGY (2008)

Article Pharmacology & Pharmacy

Assessment of basic indirect pharmacodynamic response models with physiological limits

ZL Yao et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2006)

Article Biochemistry & Molecular Biology

Expression and function of NJ-1 surface antigen in megakaryopoiesis

H Tang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

Identification of an erythroid active element in the transferrin receptor gene

CN Lok et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)