On-the-fly analysis of chloride and bromide in drug samples using NMR spectroscopy

A look over the horizon shows that the excellent principle of quantitative NMR spectroscopy can also be applied to unreceptive quadrupolar nuclei. Drugs are often present as HCl or HBr salts. The nuclei Cl-35 and Br-79 can also be excellently determined qualitatively and quantitatively by NMR when they are present in ionic form. External calibration is used, which has proven to be extremely stable. The validation parameters of the methods already accredited to ISO 17025 are given. The methods proved to be extremely robust. The analyses can be performed practically on-the-fly. This means that the analysis can be carried out within a few minutes in addition to the actual quantitative determination of the organic components without further sample preparation.

Automated summary

The excellent principle of quantitative NMR spectroscopy can also be used for quadrupolar nuclei, allowing for qualitative and quantitative determination of ionized drug components. External calibration method, which is highly stable, has been accredited to ISO 17025. The methods are robust, and analysis can be performed quickly and conveniently.