Journal
CANCER CELL
Volume 27, Issue 4, Pages 435-436Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2015.03.014
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Funding
- NCI NIH HHS [P30 CA006973] Funding Source: Medline
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Recent clinical trials in cancer therapy have demonstrated unprecedented responses through blockade of CTLA-4 and PD-1 immune checkpoint pathways. In a provocative recent paper in Science Translational Medicine, Hatfield and colleagues demonstrate the ability of supplemental oxygen to act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.
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