N-Aminoacyl-3-amino-nido-carboranes as a Group of Boron-Containing Derivatives of Natural Amino Acids

A new group of nido-carboranyl derivatives of natural (S)-aminoacids containing from 9 to 18 boron atoms was obtained in good yields as a resultof acylation of 3-amino-1,2-dicarba-closo-dodecaborane followed by deboronation.The proposed approach is convenient and based on the use of readily availablereagents and is suitable for the synthesis of enantiopurenido-carboranyl derivativesof amino acids with various side chains, including water-soluble boron-containing amino acids (17 examples)

Automated summary

A new group of nido-carboranyl derivatives of natural (S)-amino acids containing from 9 to 18 boron atoms was successfully synthesized by acylation of 3-amino-1,2-dicarba-closo-dodecaborane followed by deboronation. The proposed method utilizes readily available reagents and is convenient for the synthesis of enantiopure nido-carboranyl derivatives of amino acids with various side chains, including water-soluble boron-containing amino acids (17 examples).