Hydropyridylation of α,β-Unsaturated Esters through Electroreduction of 4-Cyanopyridine

A mild and highly efficient method for the hydropyridylation of alpha,beta-unsaturated esters has been developed. This protocol provides the products smoothly with a wide substrate scope in an undivided cell under ambient conditions. Moreover, studies showed that the scope could be extended to other unsaturated compounds, including enones and aldehydes

Automated summary

A mild and highly efficient method for the hydropyridylation of alpha,beta-unsaturated esters has been developed. This protocol provides the products smoothly with a wide substrate scope in an undivided cell under ambient conditions. Moreover, studies showed that the scope could be extended to other unsaturated compounds, including enones and aldehydes.