Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 6, Pages 4124-4133Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02918
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Funding
- National Natural Science Foundation of China [21971138]
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A novel tandem synthesis of benzo[a]acridines is developed using N-aryl-2-propynamides and alkynes through a Tf2O-promoted intermolecular Bischler-Napieralski reaction and a TfOH-promoted intramolecular Friedel-Crafts reaction.
2-Propynamides have been never used as substrates in classic and Tf2O-promoted Bischler-Napieralski reactions. In this article, a novel tandem synthesis of benzo[a]acridines is developed from N-aryl-2-propynamides and alkynes consisting of a Tf2O-promoted intermolecular Bischler-Napieralski reaction and a TfOH-promoted intramolecular Friedel-Crafts reaction.
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