Visible-Light-Induced Dual Acylation of Alkenes for the Construction of 3-Substituted Chroman-4-ones

Heterocyclic compounds, especially oxygen-containing heterocyclic compounds, are crucial moieties in bioactive compounds and drug leads. Substituted chroman-4-ones are a kind of the most significant structural skeletons. Herein, we report a visible-light-induced dual acylation of alkenes for constructing 3-substituted chroman-4-ones, which undergoes a radical tandem cyclization reaction through carbon-carbon bond cleavage of oxime esters by a nitrogen-centered radical strategy. A series of 3-substituted chroman-4-ones were prepared with up to 86% yield.

Automated summary

Heterocyclic compounds, especially oxygen-containing heterocyclic compounds, play a crucial role in bioactive compounds and drug leads. This study presents a visible-light-induced dual acylation reaction of alkenes to construct 3-substituted chroman-4-ones, which involves a nitrogen-centered radical strategy for a radical tandem cyclization reaction through carbon-carbon bond cleavage of oxime esters. A series of 3-substituted chroman-4-ones were successfully prepared with high yields.